About My Health Careers Internship MedBlogs Contact us

Erectile Dysfunction Drug may Help to Treat Rheumatic Diseases

by VR Sreeraman on October 28, 2008 at 11:19 AM
Font : A-A+

 Erectile Dysfunction Drug may Help to Treat Rheumatic Diseases

Researchers at Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) in Lucknow say that an erectile dysfunction treatment may also be effective in treating blood vessel narrowing in rheumatic diseases.

Dr. Padmanabha Shenoy, from the department of immunology, says that when used in addition to other treatments, tadalafil is effective and well tolerated in the treatment of secondary Raynaud's phenomenon, in which blood vessels narrow abnormally when exposed to cold and blood supply to the hands and feet decreases as a result.

During the study, the research team studied the effectiveness and tolerability of tadalafil as an additional therapy to treat patients with secondary Raynaud's phenomenon, who had not successfully responded to treatment with vasodilators-a common treatment that relaxes the smooth muscles in blood vessels.

Twenty-five patients, mostly females with an average age of 37, were randomly selected to receive either tadalafil or placebo for six weeks as an add-on treatment to their usual vasodilator therapy.

After the initial six weeks, patients received a seven-day break, and then those initially administered tadalafil began taking placebo, and vice versa.

The researchers recorded the frequency and duration of Raynaud's episodes.

They also watched for the healing of existing and the appearance of new fingertip ulcers, and performed physician and patient assessments of the overall severity of Raynaud's phenomenon.

Twenty-four of the 25 patients completed the study.

It was found that when taking tadalafil, the average daily frequency and duration of Raynaud's episodes experienced by patients were less: 2.23 episodes versus 3.36, and 31.5 minutes versus 53.9 minutes respectively.

All the 24 ulcers present at the start of treatment healed while on tadalfil, compared to only three out of 13 while on placebo. One new fingertip ulcer was reported while taking tadalafil; 13 new ulcers were reported while on placebo.

The researchers also said that patients' overall assessments, as well as physicians' overall assessments of Raynaud's phenomenon, significantly improved while patients were taking tadalafil, without any serious side effects.

"This research has proven the excellent efficacy of tadalafil in the treatment of the Raynaud's phenomenon and ischemic ulcers secondary to it. This study also generates a new hope in the treatment of scleroderma, which is currently incurable.

It has to be seen in further studies whether tadalafil can improve survival in scleroderma patients," says Padmanabha Shenoy.

The findings of the study were presented at the American College of Rheumatology Annual Scientific Meeting in San Francisco, California.

Source: ANI

News A-Z
News Category
What's New on Medindia
Memory Loss - Can it be Recovered?
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drugs In Impotence Drug Toxicity Erectile Dysfunction Priapism Signature Drug Toxicity Andropause / Male Menopause Premature Ejaculation Drugs Causing Sexual Problems Peyronie´s Disease Drugs for Erectile Dysfunction 

Recommended Reading
Drugs In Impotence
Encyclopedia section of medindia gives information about the Impotence...
What is arthritis?
The pain in the joints can be effectively eased through the practice of yoga, which gives ......
Andropause / Male Menopause
Andropause or male menopause causing low libido in a man is due to decreasing level of male hormones...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Causing Sexual Problems
Sexual problems occur in males as well as in females. Drugs affecting the nervous and our endocrine...
Drugs for Erectile Dysfunction
Erectile dysfunction linked to physical and psychological reasons can be treated with drugs to have ...
Erectile Dysfunction
Erectile dysfunction (ED) is the inability to develop or maintain an erection of the penis during se...
Peyronie´s Disease
Peyronie''s disease is caused by scar tissue along the length of the penis, which causes the penis t...
Premature Ejaculation
Premature ejaculation is ejaculation that occurs before either of the partners is ready for it....
Priapism is persistent painful erection that lasts for more than four hours and is unrelated to sexu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use