Environmental Toxins may Impair the Fertility of Future Generations

Exposure to environmental pollutants can cause modifications in brain development, which can affect sexual development and fertility for several generations, reveals a new study. The findings of the study are presented at the Endocrinology annual meeting 2019.

The offspring of pregnant rats exposed to a mixture of common endocrine-disrupting chemicals (EDCs), at doses equivalent to those commonly experienced by people, showed impairments in sexual development and maternal behavior that were passed on through several generations.

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‘Current levels of pollutants in our environment may already be causing long-lasting harm to people. Hence, measures should be taken by people and agencies to minimize exposure to such toxins. ’
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These findings suggest that current levels of endocrine-disrupting chemicals in our environment may already be causing long-lasting harm and that people and agencies should take measures to minimize exposure.

Endocrine-disrupting chemicals can interfere with the normal function of our hormones and have previously been associated with infertility and altered sexual development in animals and people. We are exposed to hundreds of these pollutants in our daily lives, as they are used in the manufacture of plastics, pesticides, and medicines.

However, the extent of the damage being done to our health, and the consequences to future generations remains unclear. Rodent studies have suggested that exposure to EDCs can affect brain development through several generations, but the generational effects on sexual development and reproduction have not previously been investigated.

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In this study, David Lopez Rodriguez a graduate student in Anne-Simone Parent's lab at the University of Liege in Belgium monitored the sexual development of three generations of rats, whose parent generation only were exposed to a mixture of common EDCs during pregnancy and lactation. The female rats born in the first and second generation showed impairments in their care for their own pups.

However, the female rats in the second and third generation exhibited a delayed onset of puberty and altered reproductive cycle and ovarian follicle development, indicating that their fertility was affected, even though they were never themselves exposed to the EDCs. These changes were associated with altered gene expression in their brains that are known to affect how reproductive hormones are regulated.

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Prof Parent says, "Our results raise real concerns about the effects of these pollutants in our environment. We found the effects of EDCs in generations of animals that had not been directly exposed to the chemicals. We exposed the parent generation only and found long-term effects on fertility. Of course, in everyday life, this would not happen, and exposure to these harmful chemicals would continue, which means even more damage could be done."

The team are now interested in how the changes are carried through generations and are looking at whether impaired maternal care is the trigger for the altered development in the following generations.

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Mr. Rodriguez comments, "These findings raise questions about the legacy we are leaving future generations. Current European legislation on EDCs does not consider how mixtures of low dose pollutants in our environment could be causing harm and affecting our children and wildlife in future generations, and our data suggest an urgent need to follow the precautionary principle."

Source-Eurekalert