Endogamy may Raise Infertility Risk in Indian Men

by Iswarya on  April 22, 2019 at 5:44 PM Menīs Health News
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Deletions of the Y chromosomes which is responsible for the production of sperms may cause infertility in Indian men, reports a new study. The findings of the study are published in the journal Scientific Reports.
Endogamy may Raise Infertility Risk in Indian Men
Endogamy may Raise Infertility Risk in Indian Men

The study illustrates how the ethnicity, endogamy and long-time geographical isolation of Indian populations might have played a major role in the high frequencies of deletion events.

According to the researchers, including K. Thangaraj from Centre for Cellular and Molecular Biology, deletions in the AZoospermia Factor (AZF) regions on the human Y chromosome are reported as one of the most common causes of severe testiculopathy and spermatogenic defects leading to male infertility.

For the study, the researchers screened blood samples of 973 infertile men, consisting of 771 azoospermia (complete absence of sperm), 105 oligozoospermia (low sperm count) and 97 oligoteratozoospermia (low sperm count with abnormal shape and size) patients.

The deletion screening was carried out using AZF-specific markers.

The experiments were carried in accordance with the relevant guidelines and regulations approved for research on human samples.

The study revealed deletion events in a total of 29.4 percent of infertile Indian men. Of these, non-allelic homologous recombination events accounted for 25.8 percent.

Indian populations are unique in their origin and have been practicing endogamy for the last two thousand years, and therefore it is important to add a study of the frequencies of AZF deletions on the Y chromosome and their association with fertility in Indian idiopathic infertile men to similar studies from other parts of the world, the researchers said.

Source: IANS

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