(Vol. 9, No. 14, 2014), rat models of an avulsion injury to the left brachial plexus root (associated with upper-limb chronic neuropathic pain) were given electroacupuncture stimulation at bilateral Quchi (LI11), Hegu (LI04), Zusanli (ST36) and Yanglingquan (GB34).
After electroacupuncture therapy, chronic neuropathic pain in the rats' upper limbs was significantly attenuated. Immunofuorescence staining showed that the expression of β-endorphins in the arcuate nucleus was significantly increased after therapy.
Thus, Shenyu Zhang and co-workers from Huashan Hospital, Fudan University, China, indicate that electroacupuncture can attenuate neuropathic pain after brachial plexus injury through upregulating β-endorphin expression.