A rapid, but short-acting, intravenous drug called propofol is preferentially used for the induction and maintenance of anesthesia. Propofol can inhibit inflammation and suppress the secretion of the proinflammatory cytokines interleukin-1, interleukin-6 and tumor necrosis factor alpha from astrocytes, and enhance the synthesis and release of the anti-inflammatory cytokine interleukin-10. Consequently, propofol can inhibit damage caused by proinflammatory cytokines and exert protective effects on the central nervous system. A recent study published in the Neural Regeneration Research (Vol. 8, No. 27, 2013) showed that after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L4-6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were alleviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration following sciatic nerve injury. Source: Eurekalert << Next-Generation Genome Sequencing can Help Researchers Find... Scientists Explore Hippocampal and Thalamic Neuronal Metabo... >> Recommended Reading Dental Anesthesia The advent of anesthesia may be regarded as a cornerstone in the development of modern dentistry. READ MORE Anaesthesia - History valuable information regarding the recent developments in the field of anesthesia READ MORE Anaesthesia - History and Origins Anaesthesia has come a long way since the days of chloroform. It is much more safe today than it was a long time ago. READ MORE Brachial Plexus Injury Brachial plexus is a network of nerves that transmits signals from the spine to shoulder, arm and hand. READ MORE Local Anesthesia Local anesthesia is a type of anesthesia generally used to block pain sensation only in a specific area of the body that needs to be anesthestized. READ MORE Sciatica Sciatica refers to the pain that is caused by irritation or compression of the sciatic nerve. Sciatic pain is felt from the low back. READ MORE Most Popular on Medindia The Essence of Yoga Blood - Sugar Chart Pregnancy Confirmation Calculator More News on: Dental AnesthesiaLocal AnesthesiaAnaesthesia - HistoryAnaesthesia - History and OriginsBrachial Plexus InjurySciaticaDiscectomy
A rapid, but short-acting, intravenous drug called propofol is preferentially used for the induction and maintenance of anesthesia. Propofol can inhibit inflammation and suppress the secretion of the proinflammatory cytokines interleukin-1, interleukin-6 and tumor necrosis factor alpha from astrocytes, and enhance the synthesis and release of the anti-inflammatory cytokine interleukin-10. Consequently, propofol can inhibit damage caused by proinflammatory cytokines and exert protective effects on the central nervous system. A recent study published in the Neural Regeneration Research (Vol. 8, No. 27, 2013) showed that after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L4-6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were alleviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration following sciatic nerve injury. Source: Eurekalert << Next-Generation Genome Sequencing can Help Researchers Find... Scientists Explore Hippocampal and Thalamic Neuronal Metabo... >> Recommended Reading Dental Anesthesia The advent of anesthesia may be regarded as a cornerstone in the development of modern dentistry. READ MORE Anaesthesia - History valuable information regarding the recent developments in the field of anesthesia READ MORE Anaesthesia - History and Origins Anaesthesia has come a long way since the days of chloroform. It is much more safe today than it was a long time ago. READ MORE Brachial Plexus Injury Brachial plexus is a network of nerves that transmits signals from the spine to shoulder, arm and hand. READ MORE Local Anesthesia Local anesthesia is a type of anesthesia generally used to block pain sensation only in a specific area of the body that needs to be anesthestized. READ MORE Sciatica Sciatica refers to the pain that is caused by irritation or compression of the sciatic nerve. Sciatic pain is felt from the low back. READ MORE Most Popular on Medindia The Essence of Yoga Blood - Sugar Chart Pregnancy Confirmation Calculator More News on: Dental AnesthesiaLocal AnesthesiaAnaesthesia - HistoryAnaesthesia - History and OriginsBrachial Plexus InjurySciaticaDiscectomy