About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Effect of Propofol on the Sciatic Nerve Explored

by Kathy Jones on November 3, 2013 at 11:10 PM
Font : A-A+

 Effect of Propofol on the Sciatic Nerve Explored

A rapid, but short-acting, intravenous drug called propofol is preferentially used for the induction and maintenance of anesthesia.

Propofol can inhibit inflammation and suppress the secretion of the proinflammatory cytokines interleukin-1, interleukin-6 and tumor necrosis factor alpha from astrocytes, and enhance the synthesis and release of the anti-inflammatory cytokine interleukin-10. Consequently, propofol can inhibit damage caused by proinflammatory cytokines and exert protective effects on the central nervous system. A recent study published in the Neural Regeneration Research (Vol. 8, No. 27, 2013) showed that after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L4-6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were alleviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration following sciatic nerve injury.

Advertisement


Source: Eurekalert

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Black Tea Protects against Blood Pressure and Heart Diseases
Green Mediterranean Diet may Help Repair Age-Related Brain Damages
Cervical Cancer Awareness Month 2022
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Dental Anesthesia Local Anesthesia Anaesthesia - History Anaesthesia - History and Origins Brachial Plexus Injury Sciatica Discectomy 

Recommended Reading
Dental Anesthesia
The advent of anesthesia may be regarded as a cornerstone in the development of modern dentistry....
Anaesthesia - History
valuable information regarding the recent developments in the field of anesthesia ...
Anaesthesia - History and Origins
Anaesthesia has come a long way since the days of chloroform. It is much more safe today than it wa...
Brachial Plexus Injury
Brachial plexus is a network of nerves that transmits signals from the spine to shoulder, arm and .....
Local Anesthesia
Local anesthesia is a type of anesthesia generally used to block pain sensation only in a specific a...
Sciatica
Sciatica refers to the pain that is caused by irritation or compression of the sciatic nerve. Sciati...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)