Medindia LOGIN REGISTER
Medindia
Advertisement

Efavirenz More Effective Than Nevirapine in AIDS Treatment

by Gopalan on October 15, 2008 at 4:42 PM
 Efavirenz More Effective Than Nevirapine in AIDS Treatment

AIDS patients taking the antiretroviral drug efavirenz are less likely to experience virologic failure and more likely to adhere to treatment than those taking nevirapine, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

Nevirapine is the most frequently prescribed drug for patients undergoing highly active antiretroviral therapy (HAART) for the treatment of HIV/AIDS in sub-Saharan Africa, where the study was conducted.á The study is published in the October 18, 2008 issue of the journal AIDS.

Advertisement

"Our findings add to existing limited evidence that efavirenz-based therapies produce a more favorable virological and clinical outcome than nevirapine," said Jean Nachega, lead author of the study and associate scientist with the Bloomberg School's Department of International Health. "Patients started on nevirapine had an increased risk of virologic failure and death and were significantly less likely than those started on efavirenz to achieve high treatment adherence."

"Given the rapid roll-out of antiretroviral programs in Africa and the frequent use of first-line nevirapine-based HAART in such programs the assumption that efavirenz and nevirapine are equally effective needs to be reassessed," said Nachega, who is also professor and director of the Centre for Infectious Diseases at Stellenbosch University in South Africa.
Advertisement

Hence, he stressed, "there is a critical need for a large randomized clinical trial to definitively compare the outcomes of efavirenz and nevirapine and for acceleration of efforts to develop lower cost formulations of efavirenz, including generic, fixed-dose combinations in Africa."

Nachega, in collaboration with Gary Maartens, professor of Medicine at University of Cape Town, and several other colleagues from the University of Cape Town in South Africa, examined the records of 2,817 HIV- infected adults currently enrolled in Aid for AIDS, a private-sector employer-subsidized disease management program in Africa. Participants were HAART na´ve adults who began nevirapine-based or efavirenz-based therapies between January 1998 and September 2004.

Researchers determined how often patients requested reimbursement for their purchases of nevirapine- or efavirenz-based HAART to estimate adherence to their treatment regimens. They also evaluated patients CD4 counts, viral load changes and mortality, which are measurements that indicate how well a treatment is working. Program participants were in nine countries in Africa with the majority in South Africa.

Current World Health Organization guidelines recommend the use of a non-nucleoside reverse transcriptase inhibitor such as nevirapine or efavirenz in resource limited settings. Nearly 67 percent of countries in sub-Saharan Africa recommend nevirapine-based regimens for first line therapy because it is available at a lower cost and in a variety of generic fixed-dose combination regimens. In contrast, the U.S. Department of Health and Human Services and the International AIDS Society-USA both recommend the use of efavirenz because it has a more favorable toxicity profile and greater efficacy.

Source: Medindia
GPL/SK
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest AIDS/HIV News

Concerning HIV Surge in India Amid AIDS Progress
The 35th World AIDS Day (WAD) marks an opportunity to review strides in HIV prevention, control, and management, acknowledging achievements.
World AIDS Day 2023 Emphasizes Community Leadership's Power to End HIV Crisis
World AIDS Day 2023 focuses on the theme 'Let Communities Lead,' emphasizing the power of the communities most affected by HIV in bringing an end to AIDS.
HIV-Preventive Drug-PrEP's Usage Barriers Among Young Men
Young men involved in sexual activity with other guys are less aware and stigmatized to access PrEP, an HIV prevention drug.
18 of 20 Vietnam Monkeypox Cases Test HIV-Positive
Though monkeypox can affect anyone, CDC research states that approximately 40% of people diagnosed with monkeypox in the US also test positive for HIV.
HIV Vaccine Clinical Trial Initiates in the United States and South Africa
The Phase 1 trial for a preventive HIV vaccine candidate has initiated enrollment in both the United States and South Africa.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Efavirenz More Effective Than Nevirapine in AIDS Treatment Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests