Ebola Virus Mutation Not as Rapid as Scientists Feared

by Julia Samuel on Mar 27 2015 10:50 AM

Ebola Virus Mutation Not as Rapid as Scientists Feared
Finally, there is some good news for scientists involved in treating Ebola and preventing its spread. The Ebola virus is not mutating quickly as scientists had feared, though previous research studying 99 virus genomes found a large number of mutations.
Previously, research findings suggested that Ebola was mutating twice as quickly as in the past. But scientists who sequenced four Ebola samples taken in Mali between October and November found no significant genetic changes compared to samples taken at the beginning of the epidemic in March 2014.

"The Ebola virus in the ongoing West African outbreak appears to be stable; that is, it does not appear to be mutating more rapidly than viruses in previous Ebola outbreaks, and that is reassuring," said Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases (NIAID).

Ebola diagnostic tests, antibodies and experimental vaccines are based on the genetic make-up of the virus at a particular moment. If too much genetic variation occurs, diagnosis of new, mutated forms might not be possible and vaccines and antibodies could become ineffective. Mutations could also potentially lead to more severe symptoms or a virus that spreads more easily, the scientists said.

In August 2014, virologists studying 99 virus genomes from patients in Sierra Leone found a large number of mutations. But in the study published recently, the Ebola samples collected in Mali were found to be similar to those collected elsewhere in the past. The new data "adds yet more confidence that a vaccine strategy should work," said Jim Kent of the University of California, Santa Cruz, who has set up an Ebola virus genome database.

Kristian Andersen, co-author of the earlier Sierra Leone study, Broad Institute, warned that new treatments and vaccines could result in virus mutations that will help Ebola survive them. Ebola has killed more than 10,000 people in west Africa out of nearly 25,000 infected since the start of 2014, mainly in Liberia, Sierra Leone and Guinea.