A study co-directed by the Barcelona Institute for Global Health (ISGlobal), an institution supported by "la Caixa", and the French Institute for Health and Biomedical Research (INSERM), in collaboration with other European teams, concludes that early life exposure to different chemicals - parabens, phthalates, and perfluoroalkyl substances (PFAS) - is associated with reduced lung function in children.
The study was performed with data from more than 1,000 mother-child pairs and is one of the first to apply a comprehensive exposome approach.
"This is the first study that applies an exposome approach to identify associations between pre- and childhood exposure to a range of important environmental factors and impairment of lung function, thereby representing a new paradigm in environmental health research", explains Martine Vrijheid, ISGlobal researcher and co-coordinator of the study.
The new study, performed under the European HELIX project, analyzed data from 1,033 mother-child pairs from six European countries: Spain, France, Greece, England, Lithuania, and Norway. The researchers measured 85 exposures during pregnancy and 125 during childhood, relating to outdoor, indoor, chemical and lifestyle factors. Lung function was measured by spirometry in children at 6 and 12 years of age.
The results show that prenatal exposure to two types of perfluoroalkyl substances, aka PFAS, - PFOA and PNFA- was associated with a decrease in lung function. PFAS are used as stain and water repellents and are found in many household products and food packages. They can be absorbed by the organism, through food or water for example, and then be passed to the unborn baby through the placenta.
Regarding exposures during childhood, the study identified nine exposures associated with impaired lung function. Five phthalate metabolites including DEHP and DINP which are used as a plasticizer and can be ingested, inhaled or absorbed through the skin - showed the strongest association. An association was also found with ethyl-paraben, a phenol compound used in cosmetics, and with copper, which in the general population is ingested mainly through drinking water and diet. Finally, house crowding and high density of facilities around the school were also associated with lower lung function.
"These findings have important implications for public health," concludes Martine Vrijheid. "Preventive measures to reduce exposure to the chemical substances identified, including a stricter regulation and the labeling of consumer products to better inform the public, could help prevent lung function impairment in childhood and benefit health in the long-term," she adds.
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