About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Early Exposure to Bisphenol A may Harm Testis Function in Adulthood

by VR Sreeraman on June 22, 2010 at 12:20 PM
Font : A-A+

 Early Exposure to Bisphenol A may Harm Testis Function in Adulthood

A new study conducted in animals has shown that exposure to environmental levels of the industrial chemical bisphenol A, or BPA, in the womb and early life may cause long-lasting harm to testicular function.

BPA, or bisphenol A, is a chemical inside some plastics and most canned foods we eat.

Advertisement

"We are seeing changes in the testis function of rats after exposure to BPA levels that are lower than what the Food and Drug Administration and Environmental Protection Agency consider safe exposure levels for humans," said Benson Akingbemi, the study's lead author and an associate professor at Auburn (Ala.) University.

"This is concerning because large segments of the population, including pregnant and nursing mothers, are exposed to this chemical," Akingbemi added.
Advertisement

Many hard plastic bottles and canned food liners contain BPA, as do some dental sealants. BPA acts in a similar manner as the female sex hormone estrogen and has been linked to female infertility.

This chemical is present in placenta and is able to pass from a mother into her breast milk. In their study of the male, Akingbemi and colleagues saw harmful effects of BPA at the cellular level, specifically in Leydig cells.

These cells in the testis secrete testosterone, the main sex hormone that supports male fertility. After birth, Leydig cells gradually acquire the capacity for testosterone secretion, Akingbemi explained.

The process of testosterone secretion was decreased in male offspring of female rats that received BPA during pregnancy and while nursing. The mothers were fed BPA in olive oil at a dose of either 2.5 or 25 micrograms of BPA per kilogram of body weight.

Akingbemi said this is below the daily upper limit of safe exposure for humans, which federal guidelines currently put at 50 micrograms per kilogram of body weight.

A control group of pregnant rats received olive oil without BPA. Male offspring, after weaning at 21 days of age, received no further exposure to BPA.

Using a combination of analytical methods, the investigators studied the development of Leydig cells in male offspring. The capacity for testosterone secretion was assessed at 21, 35 and 90 days of age.

The amount of testosterone secreted per Leydig cell was found to be much lower in male offspring after early-life exposure to BPA than in offspring from control unexposed animals.

"Although BPA exposure stopped at 21 days of age, BPA's effects on Leydig cells, which were seen immediately at the end of exposure and at 35 days, remained apparent until 90 days of age, when the rats reached adulthood. Therefore, the early life period is a sensitive window of exposure to BPA and exposure at this time may affect testis function into adulthood," Akingbemi said.

The results were presented at The Endocrine Society's 92nd Annual Meeting in San Diego.

Source: ANI
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Early Exposure to Bisphenol A may Harm Testis Function in Adulthood Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests