Adults at risk for key health conditions have been examined by integrating whole-genome sequencing with advanced imaging and blood metabolites. Human Longevity, Inc. (HLI), an innovator in providing data-driven health intelligence and precision health to physicians and patients, announced today the publication of a ground-breaking study in the journal Proceedings of the National Academy of Sciences (PNAS).
Data from 1190 self-referred individuals evaluated with HLI's multi-modal precision health platform, Health Nucleus, show clinically significant findings associated with age-related chronic conditions including cancer, heart disease, diabetes, chronic liver disease, and neurological disorders -- leading causes of pre-mature mortality in adults.
Quiz on Cancer
Cancer, is the second most leading cause of death worldwide. Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Take this quiz on and test how much you know about cancer.
Advertisement
‘Approximately 1 in 6 adult individuals (17.3%) had at least one pathogenic genetic variant, and when integrated with deep phenotyping (imaging, blood test, etc.), 1 in 9 (11.9%) had genotype and phenotype associations, supporting the clinical diagnosis of a genetic disorder.’
Tweet it Now
"The goal of precision medicine is to provide a path to assist physicians in achieving disease prevention and implementing accurate treatment strategies," said C. Thomas Caskey, MD, FACP, FACMG, FRSC, chief medical officer for Human Longevity, Inc., lead author of the study, and a member of the National Academy of Sciences. "Our study showed that by employing a holistic and data-driven health assessment for each individual, we are able to achieve early disease detection in adults."
Study highlights include:
Additional highly actionable findings in this self-referred cohort, most of which were not previously known, include:
![Calculate Your Lifetime Risk of Heart Attack]( "Calculate Your Lifetime Risk of Heart Attack")
Heart Risk Calculator assesses the lifetime risk for a heart attack and helps in making the right lifestyle choices to protect your heart.
Insulin resistance and/or impaired glucose tolerance (34.2%)
Elevated liver fat (29.2%)
Cardiac structure or function abnormalities such as valvular disorders (16.2%)
Significant calcified coronary artery plaque (calcium score > 100) (11.4%)
Elevated liver iron (9.3%)
Cardiac arrhythmias such as atrial fibrillation (6.1%)
Cardiac conduction disorders (4.8%)
Early stage tumors, most malignant (1.7%)
A lack of phenotype and genotype associations were observed in 5.8% of individuals with pathogenic genetic variants, further suggesting that the identification of pathogenic genetic variant(s) by sequencing alone is not sufficient for a definitive diagnosis, highlighting the importance of a multi-modal assessment.
Genomics and metabolomics associations revealed 5.1% of heterozygous carriers with phenotype manifestations, affecting serum metabolite levels, suggesting that some genetic carriers may not be completely asymptomatic.
"This study shows that the definition of 'healthy' may not be what we think it is and depends upon a comprehensive health evaluation," said J. Craig Venter, PhD, founder, Human Longevity, Inc. and a member of the National Academy of Sciences. "The data underscore Human Longevity's innovative approach to helping clinicians with early detection and personalized treatments, potentially achieving better health outcomes for patients."
"Our traditional approach to the annual health assessment has been very superficial and will need to be replaced by data-driven measures that will be made possible as costs continue to decline for whole- genome sequencing, advanced imaging, especially MRI, and specialized blood analytics," said David Karow, MD, PhD, president and chief innovation officer, Human Longevity, Inc.
Source: Eurekalert
Additional highly actionable findings in this self-referred cohort, most of which were not previously known, include:
Calculate Your Lifetime Risk of Heart Attack
Heart Risk Calculator assesses the lifetime risk for a heart attack and helps in making the right lifestyle choices to protect your heart.
Advertisement
Insulin resistance and/or impaired glucose tolerance (34.2%)
Elevated liver fat (29.2%)
Cardiac structure or function abnormalities such as valvular disorders (16.2%)
Significant calcified coronary artery plaque (calcium score > 100) (11.4%)
Elevated liver iron (9.3%)
Cardiac arrhythmias such as atrial fibrillation (6.1%)
Cardiac conduction disorders (4.8%)
Early stage tumors, most malignant (1.7%)
A lack of phenotype and genotype associations were observed in 5.8% of individuals with pathogenic genetic variants, further suggesting that the identification of pathogenic genetic variant(s) by sequencing alone is not sufficient for a definitive diagnosis, highlighting the importance of a multi-modal assessment.
Genomics and metabolomics associations revealed 5.1% of heterozygous carriers with phenotype manifestations, affecting serum metabolite levels, suggesting that some genetic carriers may not be completely asymptomatic.
"This study shows that the definition of 'healthy' may not be what we think it is and depends upon a comprehensive health evaluation," said J. Craig Venter, PhD, founder, Human Longevity, Inc. and a member of the National Academy of Sciences. "The data underscore Human Longevity's innovative approach to helping clinicians with early detection and personalized treatments, potentially achieving better health outcomes for patients."
"Our traditional approach to the annual health assessment has been very superficial and will need to be replaced by data-driven measures that will be made possible as costs continue to decline for whole- genome sequencing, advanced imaging, especially MRI, and specialized blood analytics," said David Karow, MD, PhD, president and chief innovation officer, Human Longevity, Inc.
Source: Eurekalert
Nine Wonder Foods to Beat Diabetes
Certain natural foods have unique ingredients that can enhance the health of people living with diabetes. Learn about them through this slideshow.
Advertisement
 Malaria Drug to Alleviate Hearing Loss in Genetic DisordersClassic anti-malarial drug can help sensory cells of the inner ear recognize and transport an essential protein to specialized membranes using established pathways within the cell. | Advertisement
|
Advertisement
Latest Research News
New study findings delineate how aging affects the immune response following Spinal cord injury (SCI) and highlight the participation of the spinal cord meninges in repair.
A recent clinical trial suggests that the first medication therapy to reduce the progression of nearsightedness in children could be on the way.
Autoimmune disorders were found to be linked to Sjogren's, systemic lupus erythematosus, and systemic sclerosis.
Successful brain pacemaker implantation has helped a 51year old Parkinson's disease patient to revitalize her quality of life.
Recent recommendations on lifestyle behaviors to prevent progression of rheumatic and musculoskeletal diseases revealed.