Dupilumab Benefits Adolescents With Moderate-to-severe Eczema

Adolescents with moderate-to-severe atopic dermatitis or eczema could benefit from Dupilumab, according to results of a phase IIa open-label trial and a subsequent phase III open-label extension trial.

The results from these latest studies, which are reported in the British Journal of Dermatology, demonstrate the long-term safety and efficacy of the medication for up to 52 weeks of treatment.

Dupilumab works by stopping the action of certain substances in the body that cause the symptoms of eczema. Specifically, it is a monoclonal antibody against interleukin-4 receptor alpha.

‘Dupilumab could treat adolescents with atopic dermatitis which negatively affects their quality of life. It provides substantial, prolonged clinical benefit with an acceptable safety profile. ’
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"Adolescents with moderate-to-severe atopic dermatitis have a high disease burden that negatively affects quality of life, and patients are in need of therapies that can be used long-term," said senior author Ashish Bansal, MD, of Regeneron Pharmaceuticals, Inc., in Tarrytown, New York.

"Results from these trials show that dupilumab provides substantial and sustained clinical benefit to these patients with an acceptable safety profile."

Source: Eurekalert

Atopic Dermatitis

Atopic dermatitis is an inflammatory, non-contagious, chronic skin disorder that involves scaly and itchy rashes. It is also called eczema, dermatitis or atopy.

Allergy

An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic reactions are pollen, dust mites, mold spores, pet dander, food, insect stings and medicines.

Contact Dermatitis

Contact Dermatitis is a reaction of the skin in the form of skin rashes on coming into contact with certain irritants or allergens.

Eczema: Miracles with Homeopathy

Eczema is a chronic inflammatory skin disease characterized by severe itching, redness, scaling and crusting. Homoeopathy can cure eczema.

Skin Disorder

Skin types can range from oily to dry, extreme dryness accompanied by rashes and itching can often denote the presence of a skin problem or skin disorder.