About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Drug For Preserving Brain Function Post-Heart Attack

by Tanya Thomas on March 4, 2011 at 9:28 AM
Font : A-A+

 Drug For Preserving Brain Function Post-Heart Attack

New research suggests that an experimental drug, which targets a brain system that controls inflammation, might help preserve neurological function in people who survive sudden cardiac arrest.

Survival rates for sudden cardiac arrest are low, but recent medical advancements have improved the chances for recovery. Many people who do survive suffer a range of disorders that relate to neurological deficits caused by loss of blood flow to the brain when their heart stops.

Advertisement

The researchers, led by a team at Ohio State University, believe these neurological problems might relate to inflammation and brain-cell death. The study revealed how the brain is damaged during cardiac arrest, as well as how a drug might counter those effects.

The scientists identified in a mouse model how the loss of blood in the brain sets off a process that attracts inflammatory compounds and kills brain cells. The study showed that these damaging effects were associated with alteration of the cholinergic system - an area of the brain that sends signals using the neurotransmitter acetylcholine to regulate inflammation.
Advertisement

Mice that were treated with an experimental drug called GTS-21, which ctivates acetylcholine, had lower levels of inflammatory chemicals and reduced damage to brain cells in the days following a surgically induced cardiac arrest and subsequent resuscitation.

"This is a drug that has been used safely in humans in clinical trials, so we think our findings have significant clinical potential," said Courtney DeVries, professor of neuroscience and psychology at Ohio State University and senior author of the study. "Another very important aspect of the study is that the drug was not given until 24 hours after resuscitation, and yet it was successful at reversing inflammatory effects in the brain. So there would be a large therapeutic window of time if this could eventually be used clinically."

The research is published in the March 2 issue of The Journal of Neuroscience.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Parkinsons Disease Parkinsons Disease Surgical Treatment Signature Drug Toxicity Brain Brain Facts Ataxia Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) 

Most Popular on Medindia

Find a Doctor Turmeric Powder - Health Benefits, Uses & Side Effects Post-Nasal Drip Noscaphene (Noscapine) Hearing Loss Calculator Iron Intake Calculator Vent Forte (Theophylline) Daily Calorie Requirements A-Z Drug Brands in India Drug Side Effects Calculator
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Drug For Preserving Brain Function Post-Heart Attack Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests