Alzheimer's disease is a progressive disease that destroys memory and other important mental functions. A team of researchers has recently suggested that a drug - donepezil - is most likely to enhance concentration, memory, alertness and moods in patients with Alzheimer's and dementia.
The study also found that the patients, who took donepezil, were more likely to experience side effects including nausea, vomiting and diarrhea than those who received a placebo. Lead author Dr Andrea Tricco from Li Ka Shing Knowledge Institute of St. Michael's Hospital in Canada said that Alzheimer's dementia is the most common form of dementia in North America and most people who have moderate to severe Alzheimer's will be on these medications.
"This analysis will give both patients and clinicians a full picture of how each of these drugs will likely affect their cognition, as well as their overall health," Tricco added. Although there have been previous reviews of the safety and effectiveness of cognitive enhancers in treating Alzheimer's dementia, the authors said this was the first to rank their comparative safety and effectiveness.
The findings indicated that 'Donepezil' was likely the most effective medication for Alzheimer's dementia across all effectiveness outcomes, including cognition, behaviour and overall health. Although there was no significant risk of serious harm, falls or reduced heart rate was associated with any of the medications in the study, the data was limited on these specific outcomes. The research appears in the Journal of the American Geriatrics Society.