Medindia
Advertisement

Drug Anastrazole Boosts Long-term Survival After Breast Cancer in Postmenopausal Women

by Bidita Debnath on May 31, 2015 at 1:31 PM

Drug Anastrazole Boosts Long-term Survival After Breast Cancer in Postmenopausal Women
After a diagnosis of localized breast cancer, women are often prescribed tamoxifen for five years to help prevent a recurrence, but researchers said that another drug, anastrazole, may work better.

The federally funded phase III study involved more than 3,100 postmenopausal women with a kind of breast cancer known as ductal carcinoma in situ, which was treated by removing the cancerous lump followed by a radiation regimen.
Advertisement

Some women were then randomly assigned to receive tamoxifen and others anastrazole.

After 10 years, 93.5% of women in the anastrazole group were living breast cancer-free, compared to 89.2% in the tamoxifen group, according to the first major study to compare the two treatments, released at the American Society of Clinical Oncology conference in Chicago.
Advertisement

"The good news is tamoxifen and anastrazole are both very effective, but it seems that women have better chances of staying well with anastrazole," said lead study author Richard Margolese, a professor of surgical oncology at The Jewish General Hospital, McGill University in Montreal, Canada.

"Women should also consider differences in side effects when discussing treatment options with their doctors."

The drugs were similarly tolerated by patients with few side effects, though anastrazole tends to speed up osteoporosis and put women at higher risk of bone fracture, while tamoxifen has been associated with higher rates of uterine cancer.

The differences in these complications were not statistically significant when the two drugs were compared, researcher said.

Both drugs block estrogen -- which can fuel the growth of hormone receptor-positive breast cancer -- but in different ways.

Tamoxifen blocks the access of estrogen to the cancer cells, while anastrazole is an aromatase inhibitor which suppresses the manufacturing of estrogen.

Women diagnosed with DCIS face an increased risk of getting invasive breast cancer later in life, but deaths from DCIS are uncommon after the tumor is removed followed by radiation therapy.

The patients were followed for an average of 8.6 years, during which time 114 breast cancers were detected in the tamoxifen group compared to 84 in the anastrazole group.

Eight women died of breast cancer in the tamoxifen group and five in the anastrazole group.

The 10-year overall survival rates were comparable in the two groups (92.5% for anastrazole and 92.1% for tamoxifen).

When looking at the subgroup of women over 60, however, researchers also found that anastrazole may not be superior to tamoxifen.

"Women with DCIS already have several great treatment options, and now they have one more," said ASCO expert Don Dizon of Massachusetts General Hospital.

"Aromatase inhibitors offer important advantages, but patients and their doctors should still consider the full range of options, including tamoxifen or even foregoing adjuvant treatment, as every approach carries its own risks and benefits."

Source: AFP
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Drug Toxicity Breast Biopsy Pagets disease of the breast Mastitis Menopause Cancer and Homeopathy Dilatation and Curettage Signature Drug Toxicity Breast Cancer Facts 

Recommended Reading
Veteran Actor Tanuja and Her Daughters Create Breast Cancer Awareness in Maharashtra
Yesteryear Bollywood heartthrob Tanuja and her two actor-daughters, Kajol and Tanisha, discussed ......
False Breast Cancer Alarm can Cause Physiological Strain in Women for Years
Women show signs of depression and stress even many years after the false alarm. Improving ......
FDA Approved New Gene Test can Help Some Breast Cancer Patients Avoid Chemo
MammaPrint and Blueprint test helps oncologists to evaluate the risk and recurrence of breast ......
Breast Biopsy
Breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or .....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Menopause
Menopause is defined as the state of permanent cessation of menstrual cycles (periods) for ......
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use