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Doubts Casts on Repeat Bowel Cancer Surgery

by Dr. Enozia Vakil on May 14, 2014 at 10:31 PM
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 Doubts Casts on Repeat Bowel Cancer Surgery

The online journal BMJ Open has published the trial today. It is the first to be restored under the restoring invisible and abandoned trials (RIAT) initiative that allows third parties to publish previously abandoned studies when the original researchers or sponsors fail to do so.

The initiative was announced last year by editors of The BMJ and PLOS Medicine as a way to complete and correct the scientific record, so that doctors and patients have access to accurate information to make decisions about treatments.

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The trial started in 1982 and examined the use of a tumour marker (carcinoembryonic antigen or CEA) to detect cancer recurrence early and prompt second look surgery. The researchers wanted to see whether this would result in better survival. Nearly 1,500 bowel cancer patients who had already had surgery took part in the trial. Those with high CEA levels, suggesting their cancer had returned, were randomised to further surgery (active arm) or to continued review (control arm).

But the trial was stopped early in 1993 when it was found that there were more deaths in the active arm than the control arm. Although there was a clear intention to publish the results, various factors led to the trial team breaking up and the data were thought to be irretrievably lost. When the RIAT initiative was announced, Professor Tom Treasure at University College London and colleagues at the University of Sussex and Imperial College London had already retrieved the archived files and were in the process of analysing the data.
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Spurred on by the initiative, their updated analysis confirms that there is no hint of a survival advantage associated with knowledge of the CEA. They acknowledge that methods of detection, imaging, and surgical resection have changed over the intervening 20 years, but they do not believe that the findings can be readily discounted. They say the new evidence "should fuel uncertainty about present day second look surgery for colorectal cancer in its various forms and hope that it will give some encouragement to undertake the randomised trials that are needed."



Source: Eurekalert
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