About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

DNA Match Between the Donor and Recipient Predicts Kidney Transplant Success

by Anjali Aryamvally on February 2, 2018 at 2:39 PM
Font : A-A+

DNA Match Between the Donor and Recipient Predicts Kidney Transplant Success

In a first study of its kind, a research team has narrowed down the genes that predict long term kidney transplant success, to a small stretch of DNA known as the HLA locus. Higher degree of genetic matches between the donor and the recipient in the HLA locus gives the best chance of long term survival, found the study by analysing data from across the UK and Ireland.

Led by the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at Guy's and St Thomas' NHS Foundation Trust and King's College London, the project aimed to find out how to improve long term success for kidney transplants. This finding could help to personalise treatment and reduce costs to the NHS as patients need less treatment or spend less time in hospital.

Advertisement


Several genes had previously been thought to predict kidney transplant survival. But now the research team have shown that it is only the matches in the HLA locus which predict transplant success in the long term.

Every kidney transplant centre in the UK and Ireland contributed anonymised DNA samples (via the UK and Ireland Renal Transplant Consortium), and EU samples were also included in the analysis. Through key collaborations with NHS Blood and Transplant and the Wellcome Sanger Institute, these DNA samples were analysed and linked with transplant and patient survival data.
Advertisement

The painstaking project took over ten years due to the level of collaboration involved, but the researchers believe international initiatives like this are key to improve patient care in the future.

Professor Graham Lord, Director of the NIHR BRC at Guy's and St Thomas', led the study. He said:

"Running a collaboration between so many centres was a real challenge. But it has paid off, as we identified that this area of DNA alone can tell us whether the match between a kidney donor and recipient will work in the long term. This has the potential to improve outcomes for transplant patients and deliver treatments that are more personalised to the health needs of individual patients."

While most genomics studies of this kind use just the data from the recipient or donor alone, this study looked at the data from two genomes - the patient donating the kidney, and the patient receiving it.

The findings suggest that patients could be offered enhanced levels of personalised treatments, along with a reduced need for immunosuppression treatment, and a reduced rate of kidney transplant rejection. Improvements like this could reduce costs to the NHS as patients need less treatment or spend less time in hospital.

This ground breaking study has also provided the platform for future work looking to understand why transplant patients are more susceptible to heart disease and cancer.

The collaboration was made possible by the NIHR Health Informatics Collaboration, which aims to make NHS clinical data more readily available to researchers and the NHS community, for the purpose of improving patient outcomes.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
Toothache
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Genetic Testing of Diseases Kidney Epigenetics Kidney Health Stones in Urinary Tract 

Recommended Reading
First Robotic Kidney Transplant Performed in Telangana
Telangana's first successful robot-assisted kidney transplant was performed by a team of doctors ......
Kidney Transplant Success Rates Improves in Kids, Infants
Journal of the American College of Surgeons study reports single-center pediatric kidney transplant ...
A Successful Kidney Transplant Between Hindu-Muslim Families
Humanity played a major role, when a hindu and a muslim woman donated one of their kidneys to each ....
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Epigenetics
In the recent years ‘epigenetics’ represents inheritable changes in gene expression that do not incl...
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex laborat...
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use