About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Discovery Paves Way for Effective Pain Treatments

by Sheela Philomena on April 5, 2012 at 9:19 AM
Font : A-A+

 Discovery Paves Way for Effective Pain Treatments

Recent discovery paves way for improved painkillers, say researchers.

Morphine is an extremely important drug for pain relief, but it can lead to a range of side-effects - such as patients developing tolerance to morphine and increased sensitivity to pain. Until now, how this occurs has remained a mystery.

Advertisement

The team from Colorado and Adelaide has shown for the first time how opioid drugs, such as morphine, create an inflammatory response in the brain - by activating an immune receptor in the brain.

They have also demonstrated how this brain immune receptor can be blocked, laying the groundwork for the development of new therapeutic drugs that improve the effectiveness of morphine while reducing many of its problematic side-effects.
Advertisement

The results of this research are published today in the Proceedings of the National Academy of Sciences (PNAS).

"Because morphine is considered to be such an important drug in the management of moderate to severe pain in patients right around the world, we believe these results will have far-reaching benefits," says study co-author ARC Research Fellow in the University of Adelaide's School of Medical Sciences.

Dr Hutchinson's team, including University of Adelaide colleague conducted studies in mice to validate the work done at the University of Colorado by the teams of Assistant Professor Hubert Yin.

"For some time it's been assumed that the inflammatory response from morphine was being caused via the classical opioid receptors," says Dr Hutchinson.

"However, we found instead that morphine binds to an immune receptor complex called toll-like receptor 4 (TLR4), and importantly this occurs in a very similar way to how this receptor detects bacteria.

"Our experiments in mice have shown that if this relationship with the immune receptor is disrupted, it will prevent the inflammatory response.

"This is an exciting result because it opens up possibilities for future drugs that promote the beneficial actions of morphine while negating some of the harmful side-effects. This could lead to major advances in patient and palliative care," he says.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thoracic Outlet Syndrome 

Most Popular on Medindia

Indian Medical Journals A-Z Drug Brands in India Daily Calorie Requirements Vent Forte (Theophylline) Color Blindness Calculator Iron Intake Calculator Blood - Sugar Chart Find a Doctor How to Reduce School Bag Weight - Simple Tips Diaphragmatic Hernia
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Discovery Paves Way for Effective Pain Treatments Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests