A new study has revealed the anti-inflammatory mechanism of fasting and dieting.
Researchers at Yale School of Medicine have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis and Alzheimer's disease.
Take Dieting Advice from a Friend to Combat Obesity
Is a new exercise program or diet working for a friend? If so, there's a good chance that you will try it too.
Advertisement
The researchers described how the compound Beta-hydroxybutyrate (BHB) directly inhibits NLRP3, which is part of a complex set of proteins called the inflammasome that drives the inflammatory response in several disorders including autoimmune diseases, type 2 diabetes, Alzheimer's disease, atherosclerosis, and autoinflammatory disorders.
Researcher Vishwa Deep Dixit said that these findings are important because endogenous metabolites like BHB that block the NLRP3 inflammasome could be relevant against many inflammatory diseases, including those where there are mutations in the NLRP3 genes.
![New Miracle Jab is Better Than]( "New Miracle Jab is Better Than")
A new injection called Liraglutide has been developed that has helped people shed an average 19lbs a year, so it has been considered better than dieting or exercising.
BHB is a metabolite produced by the body in response to fasting, high-intensity exercise, caloric restriction, or consumption of the low-carbohydrate ketogenic diet. Dixit said it is well known that fasting and calorie restriction reduces inflammation in the body, but it was unclear how immune cells adapt to reduced availability of glucose and if they can respond to metabolites produced from fat oxidation.
The team introduced BHB to mouse models of inflammatory diseases caused by NLP3. They found that this reduced inflammation, and that inflammation was also reduced when the mice were given a ketogenic diet, which elevates the levels of BHB in the bloodstream.
The results suggest that the endogenous metabolites like BHB that are produced during low-carb dieting, fasting, or high-intensity exercise can lower the NLRP3 inflammasome, added Dixit.
The study is published online in Nature Medicine.
Source: ANI
New Miracle Jab is Better Than 'Dieting or Exercising'
A new injection called Liraglutide has been developed that has helped people shed an average 19lbs a year, so it has been considered better than dieting or exercising.
Advertisement
BHB is a metabolite produced by the body in response to fasting, high-intensity exercise, caloric restriction, or consumption of the low-carbohydrate ketogenic diet. Dixit said it is well known that fasting and calorie restriction reduces inflammation in the body, but it was unclear how immune cells adapt to reduced availability of glucose and if they can respond to metabolites produced from fat oxidation.
The team introduced BHB to mouse models of inflammatory diseases caused by NLP3. They found that this reduced inflammation, and that inflammation was also reduced when the mice were given a ketogenic diet, which elevates the levels of BHB in the bloodstream.
The results suggest that the endogenous metabolites like BHB that are produced during low-carb dieting, fasting, or high-intensity exercise can lower the NLRP3 inflammasome, added Dixit.
The study is published online in Nature Medicine.
Source: ANI
Men are Better at Dieting Than Women: Study
Men are better at dieting than women, as men lose weight faster and find it easier to keep off, finds a new study.
Advertisement
25 Percent of 'Dieting Women' Lecture Friends on Food HabitsAlmost half of dieting women transform into 'Food Bores' by endorsing diet tips to their peers, finds new survey. | Advertisement
|
Advertisement
Recommended Reading
Latest Research News
This study could be important in helping to identify a healthy lifestyle pattern that could significantly reduce the risk of mortality in people with osteoarthritis.
The study offers insights into how psoriasis can trigger diabetes, heart disease, and inflammatory bowel disease.
Utilizing microparticles for therapy could mark a significant milestone in the fight against multiple sclerosis (MS) and other autoimmune diseases.
A study revealed that children with drug-resistant epilepsy (DRE) had the highest survival rate beyond 10 years when they underwent cranial epilepsy surgery.
From childhood through adolescence, the brain constantly changes, and researchers are making strides in identifying a potential treatment target for neuropsychiatric disorders.