Medindia LOGIN REGISTER
Medindia
Advertisement

Diagnosis of Breast Cancer Enhanced Through MR Spectroscopy

by Medindia Content Team on September 25, 2007 at 7:07 PM
Diagnosis of Breast Cancer Enhanced Through MR Spectroscopy

A study conducted at the Memorial Sloan-Kettering Cancer Center in New York City, which focuses on non-mass enhancing breast lesions has observed that proton magnetic resonance spectroscopy (H MRS) used in combination with magnetic resonance imaging (MRI) helps radiologists in diagnosing breast cancer while eliminating the chances of false-positive results. It also ensures ruling out the need to perform invasive biopsy.

"All of the cancers present in this study were identified with MR spectroscopy," said the study's lead author, Lia Bartella, M.D., director of breast imaging at Eastside Diagnostic Imaging in New York City.

Advertisement

The American Cancer Society estimates that 212,920 women will be diagnosed with breast cancer in the United States this year. MRI is playing an increasingly important role in the screening of women at high risk for breast cancer. However, while MRI depicts more abnormal findings than other breast screening procedures, it is not 100 percent accurate in distinguishing benign from malignant lesions, resulting in a large number of breast biopsy procedures recommended on the basis of imaging findings. Currently, approximately 80 percent of breast lesions biopsied are found to be benign.

Non-mass enhancing lesions are characterized by enhancement of an area that is not a mass or lump and may extend over large or small regions. Non-mass lesions occur with benign hormonal changes, but can also signify malignancy. Biopsy is often required to distinguish benign non-mass lesions from cancer.
Advertisement

With MR spectroscopy, which adds only 10 minutes to a standard MRI exam, the radiologist is able to see the chemical make-up of a tumor. In most cases, the results indicate whether or not the lesion is cancerous without the need for biopsy.

"Non-mass enhancing lesions frequently pose a dilemma to the radiologist when evaluating the breast for the presence of cancer, especially in pre-menopausal women," Dr. Bartella said. "Potentially, the use of proton MR spectroscopy may help decrease the number of benign biopsies for non-mass enhancing lesions."

For the study, Dr. Bartella and colleagues performed H MRS on 32 non-mass enhancing breast lesions in 32 women, age 20 to 63. Twenty-five of the patients had lesions that had been labeled suspicious at MRI.

H MRS can provide radiologists with chemical information about a lesion by measuring the levels of choline compounds, which are markers of an active tumor. In the study, positive choline findings were present in 15 of 32 lesions, including all 12 cancers, giving H MRS a specificity of 85 percent and a sensitivity of 100 percent. If only the lesions with positive choline findings had been biopsied, 17 (68 percent) of 25 lesions may have been spared invasive biopsies and none of the cancers would have been missed.

"By performing MR spectroscopy of the suspicious lesion after an MRI scan, we can non-invasively see which tumors show elevated choline levels and are likely malignant," Dr. Bartella said. "This chemical information added to the information provided by MRI can eliminate the need for biopsy to find out what the lesion is made of."

Dr. Bartella hopes that in the future, MR spectroscopy will be incorporated into routine diagnostic breast MRI procedures, significantly decreasing the need for needle biopsies.

Source: Eurekalert
GAN/C
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Cancer News

New Therapy for Biliary Tract Cancer
The effects and mechanisms of microRNA-451a (miR-451a), which hinders the progression of gemcitabine-resistant biliary tract cancers, are under study.
Blood Test for Early Detection of Pancreatic Cancer
The blood test pinpointed 13 proteins capable of distinguishing between early and late stages of pancreatic cancer.
Nutrients in Beef and Dairy Promote Cancer Immunotherapy
A fatty acid present in dairy products, beef, and lamb called trans-vaccenic acid enhances immune cells' capacity to combat cancers.
Combination Therapy Holds Promise for Brain Tumor in Children
Trametinib plus dabrafenib combined therapy demonstrated a clear therapeutic benefit in children with BRAF-mutated low- and high-grade gliomas.
Urban Environments Fuel Higher Breast Cancer Rates
Examining breast cancer occurrence and stages reveals disparities in urban versus rural rates, influenced by environmental conditions and the stage of the disease.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Diagnosis of Breast Cancer Enhanced Through MR Spectroscopy Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests