About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Diabetics With Kidney Disease may Benefit by a New Drug

by Dr. Enozia Vakil on April 11, 2014 at 6:53 PM
Font : A-A+

 Diabetics With Kidney Disease may Benefit by a New Drug

Patients with both diabetes and kidney diseases can now be health benefited by a drug called atrasentan as per a new study. The findings suggest that atrasentan may help maintain the well-being of many patients who are at high risk of experiencing serious medical problems.

Individuals with type 2 diabetes have a high risk of developing additional health problems such as kidney and cardiovascular diseases. To reduce these risks, it is important to lower blood pressure and urinary protein excretion, or albuminuria. Agents called renin-angiotensin-system (RAS) inhibitors can reduce both of these; however, patients' risk of experiencing residual albuminuria remains high.

Advertisement

Atrasentan, which targets the endothelin receptor A and was initially developed to treat cancer, is known to reduce albuminuria. In two identically designed, parallel, multinational, double-blind studies, researchers tested the potential for atrasentan to further reduce albuminuria in patients who had both type 2 diabetes and kidney disease and were taking RAS inhibitors. A total of 211 patients were randomized to placebo, 0.75 mg/day atrasentan, or 1.25 mg/day atrasentan for 12 weeks. Patients in the study had CKD stages 2 and 3 with albuminuria and were also receiving maximum tolerated doses of RAS inhibitors. "This represents a patient population with the highest unmet medical need among those with diabetes," said Dick de Zeeuw, MD (University Medical Center Groningen, in the Netherlands).

Dr. de Zeeuw and his colleagues found that the low dose of atrasentan, lowered albuminuria by 36% without major side effects. In addition, atrasentan lowered blood pressure and cholesterol levels. The higher dose lowered albuminuria to a similar extent but caused more fluid retention. "Although atrasentan increased weight, the incidence of peripheral edema, congestive heart failure, and other adverse events was similar between treatment groups," said Dr. de Zeeuw. While the precise mechanism by which atrasentan protects the kidneys is unclear, it's thought that the drug has beneficial effects on blood vessels in the kidneys while also reducing kidney inflammation and scarring.
Advertisement

"Although this study demonstrates that atrasentan treatment results in clinically significant albuminuria reduction with minimal fluid overload-related or cardiovascular side effects, a larger study on hard renal and/or cardiac outcomes is needed to further support these findings," said Dr. de Zeeuw. A larger ongoing phase 3 study (SONAR; ClinicalTrials.gov identifier NCT01858532) will shed more light on the kidney and cardiovascular protective effects of atrasentan.

In an accompanying editorial, Kiran Chandrashekar, MD and Luis Juncos, MD (University of Mississippi) noted that there is a critical need to develop additional therapies to improve the treatment of diabetic nephropathy and that endothelin inhibitors hold considerable promise. "This study was a success in that they identified a dose of atrasentan that provided a favorable risk/benefit ratio in the patient population studied, therefore providing a dose that will be used in future studies," they wrote. "While this is a positive step forward, it should be noted that this is just one of several steps that need to be taken."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Clinical Trials - Different Phases of the trial Diabetes - Self-Monitoring of Blood Glucose (SMBG) Diabetes and Exercise Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Signature Drug Toxicity Kidney Disease Kidney 

Most Popular on Medindia

Accident and Trauma Care A-Z Drug Brands in India Hearing Loss Calculator Calculate Ideal Weight for Infants Diaphragmatic Hernia Turmeric Powder - Health Benefits, Uses & Side Effects Drug Interaction Checker Color Blindness Calculator Nutam (400mg) (Piracetam) Blood Pressure Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Diabetics With Kidney Disease may Benefit by a New Drug Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests