About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Diabetes, Obesity Treatments may Be Derived from Body Clock-metabolism Link

by Rajashri on July 26, 2008 at 3:47 PM
Font : A-A+

 Diabetes, Obesity Treatments may Be Derived from Body Clock-metabolism Link

A molecular link between circadian rhythms, our own body clock, and metabolism has been discovered by researchers at the University of California, Irvine. This discovery may lead to treatments for diabetes, obesity and other related diseases.

Paolo Sassone-Corsi, Distinguished Professor and Chair of Pharmacology, and his colleagues have identified that an essential protein called CLOCK that regulates the body's circadian rhythms, works in balance with another protein called SIRT1 that modulates how much energy a cell uses.

Advertisement

"This interplay has far-reaching implications for human illness and aging, and it is likely vital for proper metabolism," said Sassone-Corsi, one of the world's leading researchers on circadian rhythms.

The study appears in the July 25 issue of Cell.

Circadian rhythms of 24 hours govern fundamental physiological functions in almost all organisms. The circadian clocks are intrinsic time-tracking systems in our bodies that anticipate environmental changes and adapt themselves to the appropriate time of day.
Advertisement

Disruption of these rhythms can profoundly influence human health and has been linked to metabolic disorders, insomnia, depression, coronary heart diseases and cancer.

In 2006, Sassone-Corsi identified that the protein CLOCK is an essential molecular gear of the circadian machinery.

Now, he and his colleagues have shown that the protein SIRT1 counterbalances the function of CLOCK. Even though SIRT1's function differs from CLOCK's, the two proteins interact, creating a bond that is finely regulated in the cell.

SIRT1 senses energy levels in the cell; its activity is modulated by how many nutrients a cell is consuming. It also helps cells resist oxidative and radiation-induced stress, and for this reason SIRT1 is known to help control the process of aging.

CLOCK and SIRT1 are both part of the epigenome, which consists of proteins existing in connection with a cell's DNA that take external environmental factors and make the cell's genes behave differently, even though those genes do not structurally change.

"When this balance between these two vital proteins is upset, normal cellular function can be disrupted. Because of the role these two enzymes play, changes in our sleep patterns or our diets can directly be translated into how our cells act," said Sassone-Corsi.

Source: ANI
RAS/S
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Obesity Diabetes Bulimia Nervosa Body Mass Index Stress Relief Through Alternative Medicine Gestational diabetes Liposuction Healthy Living Battle of the Bulge 

Recommended Reading
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, .....
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces ......
Cataract - Animation
An animation of how cataract of the lens can cause blurring of images on the retina....
Battle of the Bulge
The ‘battle of bulge’ is the toughest of all battles. Once you put on weight it is so difficult to g...
Body Mass Index
Body mass index (BMI) is a simple tool that is generally used to estimate the total amount of body f...
Bulimia Nervosa
The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followe...
Gestational diabetes
The condition is not caused by a lack of insulin, but by the action of hormones produced during preg...
Liposuction
Liposuction is a cosmetic procedure, which is used to suck out the excess or abnormal fat deposition...
Obesity
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the heal...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use