About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Diabetes Drugs Could Double Women’s Risk of Bone Fracture

by Gopalan on December 10, 2008 at 2:16 PM
Font : A-A+

Diabetes Drugs Could Double Women’s Risk of Bone Fracture

Long-term use of certain diabetes drugs could double women's risk of breaking bone.

Thiazolidinediones, including rosiglitazone and pioglitzone, had already been linked to a raised risk of fractures, as well as heart problems.

Advertisement

UK and US researchers have quantified the risk, and showed that using the drugs for more than a year thins the bones significantly.

The study appears in the Canadian Medical Association Journal.

It found no increased fracture risk among men.

Two million prescriptions were written for rosigliatzone and pioglitazone in the UK alone last year.
Advertisement

The European Medicines Agency carried out a safety review of rosiglitazone and pioglitzone last year, and concluded their benefits outweighed their risks.

But the researchers argued the drugs had relatively modest therapeutic effects, and the regulators should think again.

Lead researcher Dr Yoon Loke, of the University of East Anglia, said: ''Women with type 2 diabetes are already at an increased risk of fractures - with a near doubling in the risk of hip fractures - so any additional risk from thiazolidinedione therapy could have a considerable impact on public health.''

Dr Loke said the underlying cause of the effect of thiazolidinediones was unclear, and required further research.

One suggestion is that the drugs may cause fractures by replacing bone marrow with fat cells.

However, he stressed women should not stop taking the drugs without first taking medical advice.

The latest study, also conducted by researchers at Wake Forest University in North Carolina, examined data from 10 previous trials, involving a total of 13,715 patients.

It found that year-long thiazolidinedione use among elderly, postmenopausal women with type 2 diabetes resulted in one extra fracture per 21 women.

Among younger women, aged around 56, the figure was one extra fracture per 55 women.

There is no clear evidence that other drugs used to treat type 2 diabetes, such as metformin and sulfonylurea, cause an increased risk of fractures.

Recent research into thiazolidinediones has focused on the drugs' adverse effects on the heart and cardiovascular system.

One study found that they doubled the risk of congestive heart failure, while another found rosiglitazone was associated both with increased heart attacks and a doubling of heart failure.

Dr Victoria King, of the charity Diabetes UK, said: ''We really do need further evidence through properly controlled trials before we can conclusively link thiazolidinediones to increased risk of various bone conditions in humans and determine which groups of people may be at greater risk.''

In a statement, the Medicines and Healthcare products Regulatory Authority (MHRA) said fears that thiazolidinediones raised the risk of fractures in women had been raised before, and healthcare professionals notified.

The information leaflet providing with the drug to patients already contains a warning about fracture risk.

GlaxoSmithKline, which markets rosiglitazone as Avandia, said the safety and effectiveness of the drug was backed by one of the largest clinical trial programmes ever undertaken for any medicine, with 52,000 patients studied.

Source: Medindia
GPL/L
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Drug Toxicity Fracture Diabetes Diabetic Diet Infantile Cortical Hyperostosis Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise 

Recommended Reading
Fracture-First Aid and Emergency Treatment Guide
A quick and simple First Aid guide on how to administer treatment for Fracture. Emergency first aid ...
Fracture
A fracture is a condition where the continuity of the bone is lost. Majority of bone fractures ......
Online Calculator to Check Bone Health of Women
A new online calculator has been devised in the US to help women over 50 gauge their bone health....
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, sy...
Diabetes - Essentials
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels a...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Infantile Cortical Hyperostosis
Infantile Cortical Hyperostosis is a disease of unknown cause, where bizarre thickening of the corti...
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use