Diabetes Drug Tirzepatide Holds Promise in Treating Obesity

Tirzepatide, the new anti-diabetic drug, seems to help people with obesity in losing weight significantly. The experts have hailed the drug as a game-changer. In a 72-week trial named SURMOUNT-1, participants lost around 20% of their body weight. The report has been published in the New England Journal of Medicine.

Research on Obese Participants on Low-Calorie Meals

The team of international researchers said that they had split 2,539 overweight or obese participants into four groups.

One group was given a placebo injection once a week for 72 weeks, while the other three were provided either 5 mg, 10 mg, or 15 mg of a new drug called tirzepatide.

Every participant was asked to take low-calorie meals and to ensure around 150 minutes of physical activity a week. On average, the participants had a body weight of 104.8 kg and 94.5% were obese. The majority of the people were white and female. No one had diabetes.

After the end of the 72-week period, participants who were given 5 mg of tirzepatide every week lost an average of 16.1 kg, people given 10 mg shed an average weight of 22.2 kg, and the group who had taken the 15 mg lost an average weight of 23.6 kg. The group which was given a placebo injection lost an average weight of 2.4 kg.

Around 57% of people given the highest dose shed 20% or more of body weight in comparison to 3% of people who were given the placebo.

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“We should treat obesity as we treat any chronic disease with effective and safe approaches which target underlying disease mechanisms, and these results underscore that tirzepatide may be doing just that,” said Dr. Ania Jastreboff of Yale University, who was the lead author of the research.

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Source-Medindia