About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Diabetes Drug Metformin may Help Kick Out Nicotine Addiction

by Colleen Fleiss on April 7, 2018 at 9:02 PM
Font : A-A+

Diabetes Drug Metformin may Help Kick Out Nicotine Addiction

Metformin could help treat nicotine withdrawal for people trying to quit smoking, revealed study led by researchers from the Johns Hopkins University.

The team exposed laboratory mice to a two-week regimen of nicotine and found that they displayed no withdrawal symptoms when given the diabetes drug.

Advertisement


Metaformin was also found to eliminate anxiety, irritability and other withdrawal symptoms in the rodents.

"Metformin, because of its long-term record of safety and relative lack of side effects, has 'real potential' as a smoking cessation aid if clinical trials confirm the findings in mice," Sangwon Kim, from the varsity.
Advertisement

Cigarette smoking is the leading cause of preventable illness and death.

Three medicines have been approved by the US Food and Drug Administration to help people break their addiction to nicotine, but smoking cessation rates remain low -- at about 15 per cent -- even though some studies say up to 70 per cent of smokers want to quit.

Current therapies include nicotine replacement, an antidepressant and a medication aimed at reducing the cravings for and pleasurable effects of cigarettes, none of which directly treats nicotine withdrawal symptoms, Kim said.

For the new study, published week in Proceedings of the National Academy of Sciences, the team focussed on activating an enzyme known as AMP-activated protein kinase, or AMPK, which -- among other roles -- stimulates the breakdown of glucose for energy.

The team discovered that the AMPK pathway is activated in mammals following chronic nicotine use, but is repressed during nicotine withdrawal.

They set out to find whether AMPK, stimulated by metformin, could lessen or even eliminate the symptoms of nicotine withdrawal.

They found that metformin completely prevented anxious behaviors caused by nicotine withdrawal at doses that had no effect on body weight, food consumption or glucose levels.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Drug Toxicity Diabetes Diabetic Diet Smoking And Cancer Smoking And Tobacco Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Cannabis 

Recommended Reading
Metformin - Diabetes Drug with New Therapeutic Uses
Metformin, a century old anti-diabetic drug used commonly to bring down blood sugar levels has ......
Quiz on Smoking
Approximately half the smokers die due to smoking -related diseases. But it is not just the smokers ...
Smoking Risk Calculator
Do you smoke cigarettes daily? Use medindia smoking risk calculator and calculate your reduced Life ...
How to Quit Smoking
Tired of people asking you to stop smoking around them? Don't want to be ordered around by public .....
Cannabis
Cannabis has a long history of medicinal, recreational, and industrial use and comes from a bushy pl...
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, sy...
Diabetes - Essentials
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels a...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...
Smoking And Cancer
Smoking is the most important preventable cause of cancer in the world....
Smoking And Tobacco
Encyclopedia section of medindia briefs you about the History of Tobacco...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use