About My Health Careers Internship MedBlogs Contact us

Diabetes Drug Helps Obese to Lose Weight: Study

by VR Sreeraman on October 23, 2009 at 6:11 PM
Font : A-A+

 Diabetes Drug Helps Obese to Lose Weight: Study

A hormone drug licensed for diabetes also helps obese people lose weight when used in combination with a low-fat diet and physical exercise, according to a trial published online on Friday by The Lancet.

Liraglutide, marketed as Victoza, outperformed the established anti-obesity drug orlistat, commercialised as Alli or Xenical, among 564 European volunteers, it suggests.


The 135 men and 429 women volunteers were divided into three groups.

One received daily liraglutide at four different dosages; the second received orlistat; and the third were given a harmless lookalike called a placebo.

In the fortnight before the trial, all the volunteers began a regime that combined daily exercise with a cut in calorie intake by 500 calories.

By comparison, 500 calories is roughly a quarter of the recommended daily energy intake for women, and about a fifth of the recommended intake for men.

Five months later, the liraglutide patients had each lost between 4.8 and 7.2 kilos (10.5 and 15.8 pounds) on average depending on the dosage; the orlistat volunteers had lost 4.1 kilos (9.0 pounds); and the placebo group 2.8 kilos (6.1 pounds).

Seventy-six percent of the high-dosage liraglutide takers lost more than five percent of their weight, compared with 44 percent in the orlistat group and 30 percent in the placebo group.

There was also a big reduction in "prediabetes" conditions among the liraglutide group.

Liraglutide was "well-tolerated," according to the study.

"Nausea and vomiting occurred more often in individuals on liraglutide than in those on placebo, but adverse events were mainly transient and rarely led to discontinuation of treatment."

Liraglutide, which is administered into the skin through an injector, was initially developed as a treatment to control blood glucose levels for patients with Type 2 diabetes.

But one of its impacts is to brake the emptying of the contents of the stomach into the intestine, thus prolonging a feeling of satiety.

The study was led by Arne Astrup, a professor of nutrition at the University of Copenhagen. He is also an advisor to liraglutide's manufacturers, the Danish company Novo Nordisk A/S. The study data was vetted by The Lancet, a peer-reviewed journal.

The authors say the results offer "a new mode of action" for treating obesity, for which only a few effective and safe drugs are available.

Obesity has reached epidemic-level proportions in many rich economies as well as in fast-growing emerging countries.

Over the past 20 years, the rate of obesity has tripled and is more than 30 percent in some European countries, according to an estimate published last year.

Volunteers in the study had a body mass index (BMI) of between 30 and 40. A BMI, one's weight in kilos divided by one's height in metres squared, that is above 30 is generally categorised as obese.

Source: AFP

News A-Z
News Category
What's New on Medindia
Is COVID-19 Vaccination during Pregnancy Safe?
Sensory Processing Disorder (SPD)
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Drug Toxicity Diabetes Diabetic Diet Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise Signature Drug Toxicity Stress Relief Through Alternative Medicine 

Recommended Reading
Quiz on Obesity
"We are indeed much more than what we eat, but what we eat can nevertheless help ......
Low Cholesterol Diet - PUFA & MUFA
Cholesterol - The Pivotal Chemical in Low Cholesterol Diet...
Ideal Body Weight
Calculate the ideal body weight for adults easily with Medindia's Ideal Body Weight Calculator....
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, sy...
Diabetes - Essentials
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels a...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use