Development of Medicines Made Easier With New Salt Screening Method

by Chrisy Ngilneii on  March 31, 2018 at 5:55 PM Drug News
RSS Email Print This Page Comment bookmark
Font : A-A+

The process of determining the atomic structure of biologically active substances in medicines - a key step in developing new drugs, has been made easier with a new technique developed at the University of Zurich.
Development of Medicines Made Easier With New Salt Screening Method
Development of Medicines Made Easier With New Salt Screening Method

Determining crystal structures more quickly and efficiently
A research group headed up by Bernhard Spingler, professor at the Department of Chemistry of the University of Zurich, has now modified a method that had previously been used exclusively for the crystallization of proteins, and successfully applied it to organic salts. The team was able to determine the crystal structures of several organic salts with significantly less time and effort. "As organic salts make up about 40 percent of all active pharmaceutical ingredients, this new method can greatly speed up the development of drugs," says Spingler.

Simplified screening of organic salts
The generation of solid salts of organic molecules is a key step in developing certain pharmaceutical ingredients. The positively and negatively charged particles that make up organic salts determine their properties, such as their solubility, crystal shape, ability to absorb water, melting point, and stability. The search for the ideal negatively charged anion to match the salt's positively charged cation has until now been a very resource-intensive process. Thanks to the semi-automatic combination of ion exchange screening and vapor diffusion for crystallization, this is not only done quicker and at lower costs. "We can now also determine the structures of the salt combinations directly after screening, since doing so only requires only very small amounts," adds crystallography expert Spingler.

Trainee achieves breakthrough
The breakthrough in developing the novel method was achieved by Philipp Nievergelt, a trainee who had spent 10 months in Bernhard Spingler's lab after graduating from Gymnasium. The successful junior researcher is listed as first author of the study and is now four semesters into his business chemistry studies at UZH. "The traineeship got me excited about lab work and encouraged me to continue doing research," explains Nievergelt.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

More News on:

Drug Toxicity Salt in Our Food Salt Scrub Tame your Salt Intake Smartly Low Salt Diet for Good Health 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive