Researchers have discovered a way to effectively deliver staurosporine (STS), a powerful anti-cancer compound that has vexed researchers for more than 30 years due to its instability in the blood and toxic nature in both healthy and cancerous cells.
The research took place at the University of California, San Diego School of Medicine. For the first time, the new method safely delivered STS to mouse tumors, suppressing them with no apparent side effects. The results were published online, October 20, in the International Journal of Nanomedicine.
"By itself, staurosporine shows potent activity against a number of cancer cell lines, including chemotherapy-resistant tumors. However, it also harms normal tissue," said senior author Santosh Kesari, MD, PhD, director of neuro-oncology at UC San Diego Moores Cancer Center. "With this study, we have been able to overcome the pharmacokinetic barriers to delivering staurosporine to tumors with the use of liposomes."
Liposomes are microscopic bubbles made from the same molecules as cell membranes. Researchers use these hollow spheres to deliver therapeutic agents. Anti-cancer drugs can be loaded inside, while disguising agents coat the external membrane surface to hide the cancer-killer from the immune system.