For patients with early and advanced Parkinson's disease, deep brain stimulation is now a well recognized non-pharmacological treatment to improve motor symptoms. Evidence now indicates that DBS can decrease the number and severity of non motor symptoms of patients with Parkinson's disease (PD) as well, according to a review published in the Journal of Parkinson's Disease.
"Non motor features are common in PD patients, occur across all disease stages, and while well described, are still under-recognized when considering their huge impact on patients' quality of life," says Lisa Klingelhoefer, MD, a fellow at the National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital and King's College, London.
For example, DBS of the subthalamic nucleus (STN) is effective for alleviating sleep problems and fatigue associated with PD, producing noticeable long-term improvements in sleep efficiency and the quality and duration of continuous sleep. DBS also decreases nighttime and early morning dystonia and improves nighttime mobility. "DBS can contribute to better sleep, less daytime somnolence, improved mobility, and less need for dopamine replacement therapy," says Dr. Klingelhoefer.
"Further work is required in order to fully understand the mechanisms and impact of DBS of the STN or other brain structures on the non motor symptoms of PD," concludes Dr. Klingelhoefer. She suggests that in the future, non motor symptoms of PD may become an additional primary indication for DBS.