A study by Columbia University Medical Center researchers says that more symptoms of depression and lower cognitive status are independently associated with a more rapid decline in the ability to handle tasks of everyday living in Alzheimer's patients. The study appears in this month's Journal of Alzheimer's Disease.
Although these findings are observational, they could suggest that providing mental health treatment for people with Alzheimer's disease might slow the loss of independence, said senior author Yaakov Stern, PhD, professor of neuropsychology (in neurology, psychiatry, psychology, the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H. Sergievsky Center) at CUMC.
"This is the first paper to show that declines in function and cognition are inter-related over time, and that the presence of depression is associated with more rapid functional decline," said Dr. Stern, who also directs the Cognitive Neuroscience Division of the Department of Neurology at CUMC.
"Making a prognosis for Alzheimer's disease is notoriously difficult because patients progress at such different rates," said first author Laura B. Zahodne, PhD, a postdoctoral fellow in the cognitive neuroscience division in the Department of Neurology and the Taub Institute at CUMC. "These results show that not only should we measure patients' memory and thinking abilities, we should also assess their depression, anxiety, and other psychological symptoms that may affect their prognosis."