Deadly Encaphalitis Outbreak is Due to Single Mutation in West Nile Virus

by Jayashree on Aug 25 2007 1:18 PM

Deadly Encaphalitis Outbreak is Due to Single Mutation in West Nile Virus
University of California researchers have found that the deadly encephalitis outbreaks caused by West Nile virus are a result of a single genetic mutation.
West Nile virus (WNV) is transmitted through an infected mosquito’s bite and one may not experience any signs or symptoms except a skin rash and headache. However, some people who become infected develop a life-threatening illness that includes inflammation of the brain.

The virus which mainly infects birds, was not a serious threat to humans until the mid-1990s when deadly outbreaks occurred in Israel, Romania, Russia and eventually North America.

Aaron Brault and colleagues discovered that new strains of the virus have a mutation in the gene for helicase, a protein involved in viral replication.

Researchers suggested that the virus had a selective advantage as the mutation occurred independently in each strain.

As part of the study, researchers injected American crows with a weak strain of virus engineered to have the helicase mutation to confirm their suspicion.

The experiment found that the death rate was increased from 25 per cent to nearly 100 per cent and the rate of virus replication also increased, resulting in amount of circulating viral particles rising by a factor of at least 10,000.

'Mosquitoes feeding on these birds would take in more than 1 million viral particles in a meal. This would greatly enhance the efficiency of infection,' quoted Brault, as saying.


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