About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

De-worming Drug Could Help Protect Against Periodontitis

by Sheela Philomena on November 9, 2013 at 11:03 AM
Font : A-A+

 De-worming Drug Could Help Protect Against Periodontitis

Oxantel, the drug used to treat intestinal worms may protect people from periodontitis (an advanced gum disease), say researchers.

Investigators showed in an animal model of periodontitis that the drug Oxantel inhibits this growth by interfering with an enzyme that bacteria require for biofilm formation, says corresponding author Eric Reynolds, of the University of Melbourne, Australia.

Advertisement

Researchers found that the periodontal biofilm depended for growth on the availability of iron and heme (an iron-containing molecule related to hemoglobin), and that restricting these reduced levels of the enzyme, fumarate reductase.

Since Oxantel was known to inhibit fumarate reductase in some bacteria, they then successfully tested its ability to inhibit fumarate reductase activity in Porphyromonas gingivalis, one of the major bacterial components of periodontitis biofilms. Fumarate reductase is absent from humans, making it an ideal drug target.
Advertisement

They also showed that Oxantel disrupted the growth of polymicrobial biofilms containing P. gingivalis, Tannerella forsythia, and Treponema denticola, a typical composition of periodontal biofilms, despite the fact that the latter alone is unaffected by Oxantel.

The researchers found that treatment with Oxantel downregulated six P. gingivalis gene products, and upregulated 22 gene products, all of which are part of a regulon (a genetic unit) that controls availability of heme.

The research has been published in journal Antimicrobial Agents and Chemotherapy.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sensory Processing Disorder (SPD)
First Dose of COVID-19 Vaccines May Improve Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity Periodontitis Quiz on Dental Care 

Recommended Reading
Gingivitis
Gingivitis is a common gum disease caused by poor oral hygiene. It begins with plaque deposition ......
Smart Phones Could be Used as Field Microscopes Demonstrates a Toronto Doctor
Toronto doctor turns his iPhone 4S into a field microscope to detect intestinal worms in children .....
'Obesity Linked to Periodontitis' Publishes IADR/AADR
A pilot investigation is in order to ascertain if the link between obesity and periodontal disease ....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Periodontitis
Periodontitis or pyorrhea is infection and inflammation of ligament tissues that surround and suppor...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use