Female HIV patients acquire cancer-causing forms of the human papillomavirus (HPV) that are not included in the current HPV vaccines Gardasil and Cervarix. This is according to new research from Fox Chase Cancer Center being presented at the AACR Annual Meeting 2013 on Sunday, April 7.
"People with issues in their immune system such as HIV will be at risk of acquiring HPV, as well – and the current vaccine may not fully protect them," says study author Elizabeth Blackman, MPH, research specialist at Fox Chase.
Women who had been taking HIV medications for at least 4 years, however, were less likely to carry cancer-causing forms of HPV, suggesting that treating HIV may also protect women from the consequences of HPV. "Protecting the immune system may prevent other diseases," says Blackman.
More than 40 types of HPV can infect the genital areas and at least 15 of these types are considered "high risk," meaning they can cause changes in cells that can lead to cancer. In the U.S., approximately 4,000 women die each year from cervical cancer, which almost always stems from HPV infection.
But HPV is very common—practically every sexually active person will acquire it at some point. In most cases, these infections do not lead to cancer, says Blackman, because a healthy immune system can normally clear the virus on its own. "But if your immune system is compromised, such as in HIV, you will not be able to fight off the infection," she says. "Over time, persistent infection with HPV can lead to cancer."
During the study, Blackman and her colleagues tested 176 HIV-positive women living in the Bahamas for the presence of high risk forms of HPV. They chose this population, she explains, because different strains of HPV are prominent in different geographic regions.
Previous research has also shown that other populations of women with immune system problems can acquire atypical cancer-causing forms of HPV, says Blackman.