About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Culprit Behind Obesity-related Cardiovascular Disease Identified

by VR Sreeraman on November 12, 2008 at 4:12 PM
Font : A-A+

 Culprit Behind Obesity-related Cardiovascular Disease Identified

Washington, Nov 11 (ANI): A new study by researchers at Ohio University has revealed that obesity raises levels of the hormone leptin, which can be a big threat to the cardiovascular system.

Leptin, a peptide hormone produced by fat cells, helps regulate body weight by acting on the hypothalamus to suppress appetite and burn stored fat.

Advertisement

However, an excess of fat in the body can produce too much of the hormone, which, in turn, can lower levels of bioavailable nitric oxide.

Nitric oxide, produced by the endothelial cells, supports healthy cardiovascular function by relaxing blood vessels and maintaining good blood flow, said Tadeusz Malinski, who has developed special nanosensors that can detect levels of the substance.
Advertisement

Also, Malinski found that the high levels of leptin stimulate greater production of superoxide. It reacts with nitric oxide to create peroxynitrite, a very toxic molecule that can impact DNA replication and damage endothelial cells in the vascular system.

"The nanosensors provide a more direct method of determining what processes are occurring in the body. Previously, researchers didn't have a clear idea of how this works," said Malinski, the Marvin and Ann Dilley White Distinguished Professor of Biomedical Sciences at Ohio University.

Malinski said that though obesity is closely associated with heart failure, scientists haven't fully understood the relationship.

The new study suggests that increased levels of leptin alone can cause long-term cardiovascular damage similar to hypertension, arthrosclerosis, diabetes and other disorders.

"Now that we know the exact molecules responsible for the damage, we can design a method to mollify the effect of obesity on the cardiovascular system," Malinski said.

The study was published in a recent issue of the American Journal of Physiology - Heart and Circulatory Physiology. (ANI)

Source: ANI
SRM
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Malnutrition to Obesity - The Big Leap 

Recommended Reading
Risk factors for cardiovascular disease - Introduction
Distance education for Overview of the risk factors for cardiovascular disease...
Quiz on Obesity
"We are indeed much more than what we eat, but what we eat can nevertheless help ......
Pairing Leptin and a Modest Exercise Prevents Weight Gain
Combining moderate exercise with leptin hormone, once heralded as a promising obesity treatment, ......
Malnutrition to Obesity - The Big Leap
Obesity is the root cause of problems like diabetes, heart disease, stroke, arthritis and gall bladd...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use