
A new study published online in the Journal of Leukocyte Biology provides new insight into how stress, through signaling of corticotropin-releasing factor (CRF), interacts with cells in the immune system to cause disease.
Specifically, the study identified a new role for the stress receptor CRF1, which is expressed on mast cells (critical immune cells implicated in many stress-related gastrointestinal and immune disorders such as allergy). The results showed that mast cell CRF1 is a master regulator of mast cell activity during different types of stressful challenges, including psychological stress and anaphylaxis, or severe allergic reaction.
"We all know that stress affects the mind-body connection and can cause disease. The question is, how?" said Adam Moeser, DVM PhD, associate professor and Matilda R. Wilson Endowed Chair within Michigan State University's College of Veterinary Medicine, Department of Large Animal Clinical Sciences, in East Lansing, Michigan. "This work is a critical step toward unlocking the complex mind-body connection by providing a new understanding of how stress influences the activity or the mast cell, which could lead to the discovery of new, more effective therapeutics. -- hopefully, ones that will improve quality of life for people suffering from stress-related diseases."
"There is increasing awareness of the connection between neurological signals and the immune system, but relatively little is know about the specific details of how psychological events such as stress connect to immune function," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "By identifying a key signaling pathway that is used by immune cells in both immune and psychological stress response, the authors may have uncovered a new target for therapeutics to treat physiological immune-related effects of various kinds of environmental stresses."
Source: Eurekalert
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