Lead researcher Z. Zhang will hold an oral presentation on a study titled "Fuz is Essential for Craniofacial and Tooth Development" during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research.
Fuz has been identified as a planar cell polarity effector gene and shown to be involved in ciliogenesis.
The objective of this study was to determine if fuz expression was critical for craniofacial and tooth development. In this study, fuz-/- mutant mice and mouse embryo fibroblasts were used to analyze the effect of fuz expression on tooth development and gene expression pathways, respectively. Immunohistochemical, molecular and biochemical assays were used to understand the defects and molecular mechanisms underlying the phenotype of the Fuz-/- mice.