The Corn Refiners Association (CRA) has said that it is important for people to understand the differences among various ingredients used in scientific studies that are examining the roles of natural sweeteners.
Commentators who incorrectly treat as interchangeable two distinctly different ingredients, such as pure fructose and high fructose corn syrup, create factually incorrect conclusions and mislead consumers.
Studies using pure fructose that purport to show that the body processes high fructose corn syrup differently than other sugars due to fructose content are a classic example of this problem because pure fructose cannot be extrapolated to high fructose corn syrup. The abnormally high levels of fructose used in these studies are not found in the human diet. Fructose consumption at normal dietary levels and as part of a balanced diet has not been shown to yield such results. Moreover, the presence in high fructose corn syrup of glucose in combination with fructose is a critical distinguishing factor from pure fructose.
- High fructose corn syrup contains approximately equal ratios of fructose and glucose. Table sugar also contains equal ratios of fructose and glucose. High fructose corn syrup and sugar are equally sweet and both contain four calories per gram.
- Fructose is a natural, simple sugar commonly found in fruits and honey. The absence of glucose makes pure fructose fundamentally different from high fructose corn syrup. This is because glucose has been shown to have a tempering effect on specific metabolic effects of fructose.
- There is no difference in how the body metabolizes table sugar and high fructose corn syrup. Once the combination of glucose and fructose found in high fructose corn syrup and sucrose are absorbed into the blood stream, the two types of sweetener appear to be metabolized similarly using well-characterized metabolic pathways.
- High fructose corn syrup meets the U.S. Food and Drug Administration's requirements for use of the term "natural." It is made from corn, a natural grain product and contains no artificial or synthetic ingredients or color additives.