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Counterfeit Contraceptives Found in South America

by Dr. Enozia Vakil on April 19, 2014 at 11:08 AM
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 Counterfeit Contraceptives Found in South America

Around 28 percent of batches of contraceptive pills studied in Peru were found to be either of substandard quality or falsified, a new survey revealed. Many pills released the active ingredient too slowly. Others had the wrong active ingredient. One batch had no active ingredient at all.

To detect the fake drugs, researchers at the Georgia Institute of Technology developed a sophisticated approach using mass spectrometry to quickly assess suspected counterfeit drugs and then characterize their chemical composition. The study's results highlight a growing concern for women's health in developing nations.

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"A woman who does not want to get pregnant and takes these emergency contraceptives will get pregnant," said Facundo M. Fernández, a professor in the School of Chemistry and Biochemistry, whose lab investigated the contraceptives.

The study was sponsored by the ACT Consortium through a grant from the Bill and Melinda Gates Foundation. The study was published April 18 in the journal PLOS ONE.
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Drugs are considered fake or falsified when someone makes a pirate copy of copies a patented drug, with criminal intent. Recent research has found that falsified drugs are a major problem in developing countries. Falsified emergency contraceptives have been reported in Nigeria, Ghana, Kenya, Angola, South America and even the United States. Fake drug manufacturers will copy everything from the pill to the package.

Just as concerning as counterfeit medications are other poor quality medications, such as degraded or substandard drugs. Degraded drugs were once good quality, but lost their efficacy over time, for example after prolonged exposure to the sun in an open air market. Substandard drugs are made by an approved factory, but they don't contain the right active ingredient, contain less active ingredient than they should, or might not dissolve properly. These pills either result from factory error or negligence.

Falsified drugs are the most worrisome, because they may not contain the expected active ingredient, or they may contain the wrong ingredients, including toxic compounds.

In the survey of emergency contraceptives from Peru, the researchers found that seven of the 25 batches analyzed had inadequate release of the active ingredient (levonorgestrel). One batch had no detectable level of the active ingredient.



Source: Eurekalert
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