Lecithin, a chemical found in soybeans when added to a non-steroidal anti-inflammatory drug (NSAID), increased its anticancer properties and reduced its side effects, finds a study by scientists at The University of Texas Health Science Center at Houston (UTHealth). The findings of the preclinical study appear in the journal Oncology Letters.
"The results support the potential use of NSAIDs associated with phosphatidylcholine for the prevention and treatment of colorectal cancer," said Lenard Lichtenberger, Ph.D., the study's lead investigator and a professor of integrative biology and pharmacology at McGovern Medical School at UTHealth.
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‘Lecithin found in soybeans in combination with a non-steroidal anti-inflammatory drug (NSAID), can prevent cancer and its side effects.’
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The NSAID indomethacin associated with phosphatidylcholine was studied in a head-to-head comparison with three other NSAIDs (one of them aspirin). According to the results, the combination provided superior colorectal cancer protection with less gastrointestinal bleeding. The study was conducted in a mouse model and in laboratory experiments.
Colorectal cancer is the third leading cause of cancer-related death in the United States and is expected to claim 50,630 lives this year.
NSAIDs work by decreasing the production of substances that promote inflammation, pain and fever. They are used to prevent heart disease and reduce arthritis pain. NSAIDs, notably aspirin, also guard against colorectal cancer. "Many cancers are inflammation based," he said. "The anti-inflammatory drugs also have the potential use for cancer therapy."
![COX - 2 Inhibitors]( "COX - 2 Inhibitors")
What are COX-2 Inhibitors? Why are they safer compared to NSAIDs and which conditions are best treated by these drugs. Learn more about COX-2 inhibitors.
However, when taken on a daily basis for months to years, NSAIDs can cause problems, Lichtenberger said. "The intestinal injury is worse than the stomach ulcers, for non-aspirin NSAIDs like indomethacin," he said.
"This is our latest preclinical study on the use of phosphatidylcholine to mitigate the side effects of using NSAIDs and protect against a number of cancers," he said.
Source: Eurekalert
NSAIDs work by decreasing the production of substances that promote inflammation, pain and fever. They are used to prevent heart disease and reduce arthritis pain. NSAIDs, notably aspirin, also guard against colorectal cancer. "Many cancers are inflammation based," he said. "The anti-inflammatory drugs also have the potential use for cancer therapy."
COX - 2 Inhibitors
What are COX-2 Inhibitors? Why are they safer compared to NSAIDs and which conditions are best treated by these drugs. Learn more about COX-2 inhibitors.
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However, when taken on a daily basis for months to years, NSAIDs can cause problems, Lichtenberger said. "The intestinal injury is worse than the stomach ulcers, for non-aspirin NSAIDs like indomethacin," he said.
"This is our latest preclinical study on the use of phosphatidylcholine to mitigate the side effects of using NSAIDs and protect against a number of cancers," he said.
Source: Eurekalert
Taking Misoprostol With NSAID Lowers Cardiovascular Risk
Non-steroidal anti-inflammatory drugs (NSAIDs) have been linked with rare but life-threatening cardio-renal complications.
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 People With Kidney Cancer Could be at a Real Risk From NSAIDSIbuprofen and other non-steroidal anti-inflammatory medications except aspirin could increase mortality risk in patients with kidney cancer, finds a new study. | Advertisement
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