Lecithin, a chemical found in soybeans when added to a non-steroidal anti-inflammatory drug (NSAID), increased its anticancer properties and reduced its side effects, finds a study by scientists at The University of Texas Health Science Center at Houston (UTHealth). The findings of the preclinical study appear in the journal Oncology Letters. "The results support the potential use of NSAIDs associated with phosphatidylcholine for the prevention and treatment of colorectal cancer," said Lenard Lichtenberger, Ph.D., the study's lead investigator and a professor of integrative biology and pharmacology at McGovern Medical School at UTHealth. The NSAID indomethacin associated with phosphatidylcholine was studied in a head-to-head comparison with three other NSAIDs (one of them aspirin). According to the results, the combination provided superior colorectal cancer protection with less gastrointestinal bleeding. The study was conducted in a mouse model and in laboratory experiments. ‘Lecithin found in soybeans in combination with a non-steroidal anti-inflammatory drug (NSAID), can prevent cancer and its side effects.’ Colorectal cancer is the third leading cause of cancer-related death in the United States and is expected to claim 50,630 lives this year. NSAIDs work by decreasing the production of substances that promote inflammation, pain and fever. They are used to prevent heart disease and reduce arthritis pain. NSAIDs, notably aspirin, also guard against colorectal cancer. "Many cancers are inflammation based," he said. "The anti-inflammatory drugs also have the potential use for cancer therapy." However, when taken on a daily basis for months to years, NSAIDs can cause problems, Lichtenberger said. "The intestinal injury is worse than the stomach ulcers, for non-aspirin NSAIDs like indomethacin," he said. "This is our latest preclinical study on the use of phosphatidylcholine to mitigate the side effects of using NSAIDs and protect against a number of cancers," he said. Source: Eurekalert << New Tool That Re-engineers RNA to Correct Genetic Diseases Blocking Smell Receptor in Prostate Cancer Cells Could Provi... >> Recommended Reading How to Cope with Cancer Pain Pain occurs in about 20-50% of patients with cancer. Proper therapeutic approach can help relieve and manage the condition. READ MORE COX - 2 Inhibitors What are COX-2 Inhibitors? Why are they safer compared to NSAIDs and which conditions are best treated by these drugs. Learn more about COX-2 inhibitors. READ MORE Taking Misoprostol With NSAID Lowers Cardiovascular Risk Non-steroidal anti-inflammatory drugs (NSAIDs) have been linked with rare but life-threatening cardio-renal complications. READ MORE People With Kidney Cancer Could be at a Real Risk From NSAIDS Ibuprofen and other non-steroidal anti-inflammatory medications except aspirin could increase mortality risk in patients with kidney cancer, finds a new study. READ MORE Drug Toxicity Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. READ MORE Drugs Banned in India Several drugs are either banned or withdrawn after introduction in the market. READ MORE Natural Remedies for Cholesterol – How Effective Are They? Certain natural remedies are effective in controlling high cholesterol, when aided by lifestyle changes. READ MORE Soy / Soya - A Holy Food Soy or Soya is a crop which has been cultivated from thousands of years. It belongs to the family of legumes. READ MORE Tattoos A Body Art Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look READ MORE Types of Food Allergies If you are allergic to certain food items-Watch out for what you eat READ MORE Most Popular on Medindia Accident and Trauma Care Blood - Sugar Chart Nutam (400mg) (Piracetam) More News on: Drug ToxicityCancer and HomeopathySoy / Soya - A Holy FoodSignature Drug ToxicityCancer FactsCancerTattoos A Body ArtTypes of Food AllergiesDrugs Banned in IndiaNatural Remedies for Cholesterol – How Effective Are They?