Medindia
Advertisement

Combination Therapy Shown as Effective for Higher-Risk DS/AML Patients

by Himabindu Venkatakrishnan on December 22, 2014 at 5:29 PM

 Combination Therapy Shown as Effective for Higher-Risk DS/AML Patients
Patients with higher-risk forms of myelodysplastic syndrome and acute myeloid leukemia may find that combination of drugs azacitidine and lenalidomide as an effective frontline treatment regimen. A phase two study that investigated the potential of the drugs azacitidine (AZA) and lenalidomide (LEN), demonstrated this.

Myelodysplastic syndrome (MDS) is a type of cancer in which the bone marrow does not make enough healthy blood cells, resulting in abnormal (blast) cells in the blood and/or bone marrow. Higher-risk patients experience an unusually large percentage of blasts in their blood. Patients often develop infections, anemia, or excessive bleeding. Acute myeloid leukemia (AML) is a blood cell cancer and is the most common acute leukemia affecting adults, with incidences increasing with age.
Advertisement

The study, led by Guillermo Garcia-Manero, M.D., professor of leukemia at The University of Texas MD Anderson Cancer Center, shed new light on effective dosage schedule and amounts for the drugs, something previously unknown. The combination therapy was well tolerated in the study of 88 patients.

The study results were presented today by Courtney Dinardo, M.D., assistant professor of leukemia, at the 56th Annual Meeting of the American Society of Hematology (ASH) annual conference in San Francisco and were published in the Dec. 5 issue of the ASH journal Blood.
Advertisement

"Hypomethylating (HMA) agents such as AZA and LEN are currently the front line of therapeutic choice for patients with higher-risk MDS, and also frequently employed in elderly AML patients not otherwise eligible for standard intensive therapy," said DiNardo. "A number of combination strategies are under development to improve the results of HMA therapy. Given what we know about the effectiveness of AZA and LEN in patients with MDS and AML, a scientific rationale existed to explore this therapeutic combination strategy."

DiNardo's team evaluated the administration of AZA and LEN on days 6 to 10 of a 28-day cycle of treatment. The combination therapy appeared to be effective in patients presenting with as high as 30 percent blasts or abnormal blood/bone marrow cells.

"The responses were rapid with a median of two cycles for the drugs to be effective. Treatment with this dosage and schedule was well tolerated," said DiNardo.

Members of DiNardo's study team included Naval Daver, M.D., Eliza Jabbour, M.D., Tapan Kadia, M.D., Gautam Borthakur, M.D., Marina Konopleva, M.D., Ph.D., Naveen Pemmaraju, M.D., Hui Yang, M.D., Ph.D., Yue Wei, William Wierda, M.D., Ph.D., Jorge Cortes, M.D., Farhad Ravandi, M.D., Hagop Kantarjian, M.D., and Guillermo Garcia-Manero, M.D., all of the department of leukemia; and Carlos Bueso-Ramos, M.D, Ph.D., and Keyur Patel, M.D., Ph.D., department of hematopathology.

The study was funded by the National Institutes of Health (P30 CA016672), Celgene Corporation, the Edward P. Evans Foundation, and Fundación Ramón Areces.


Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Reiki and Pranic Healing Combination Therapy for High Blood Pressure 

Recommended Reading
Quiz on Leukemia
Making up for 2.9% of all cancers, Leukemia is a serious condition. Do you know all about it? ......
New Drug Combination Promises Better Treatment Outcomes in Chronic Myeloid Leukemia (CML)
Treatment with imatinib and peginterferon alfa-2a was associated with significantly higher rates of ...
Microarray Technology May Be the Game Changer in Diagnosis of Leukemia
Microarray technology that can search millions of chromosomes quickly allows better diagnosis of ......
Leukemia / Blood Cancer
Leukemia is cancer of blood-forming tissues in the body....
Combination Therapy for High Blood Pressure
Anti-hypertensive agents are still the treatment drugs for hypertension but recent advances indicate...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use