A new study has found that the combination of obesity and smoking could lead to more health problems compared to both factors separately.
The study was conducted by researchers at Pacific Northwest National Laboratory in Richland, Washington, and was focused on how the activity of P450 enzymes was affected by cigarette smoke. The P450 enzymes have already been found to interfere with the body's reaction to prescription medications while other studies have revealed that obesity was linked with changes in the P450 enzyme activity. The study has been presented at the 246th National Meeting and Exposition of the American Chemical Society (ACS)
For this study, the researchers exposed a group of mice to cigarette smoke, second-hand smoke or no smoke at all and observed its effect on P450 enzymes activity. The researchers found that cigarette smoke was linked with increased P450 enzyme activity though obese or normal weight of mice had no influence on the activity levels. However the combination of cigarette smoke and obesity did affect the activity of other enzymes, with obesity reducing the activity levels by 100 times.