About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Combination of Hormone Therapy may Not Increase Cancer Risk

by Shirley Johanna on December 24, 2017 at 1:54 PM
Font : A-A+

Combination of Hormone Therapy may Not Increase Cancer Risk

A combination of conjugated estrogens and the drug bazedoxifene trigger the expression of genes that improve metabolism and prevent weight gain, without increasing the risk of cancer, finds the study.

University of Illinois food science and human nutrition professor Zeynep Madak-Erdogan led a group of researchers who explored the effects of conjugated estrogens and bazedoxifene on the liver by analyzing gene transcription and the metabolism of about 150 chemicals in the blood. The findings were reported in a paper published in the online journal PLOS One.

Advertisement


Bazedoxifene is commonly prescribed in combination with conjugated estrogens to prevent postmenopausal osteoporosis. It is among a class of compounds known as selective estrogen receptor modulators, which bind to estrogen receptors and either promote or block their activity.

"Once women enter menopause and estrogens are lost, their metabolism is rewired, in the sense that they often start gaining weight, their bad cholesterol increases, their good cholesterol decreases and they may become pre-diabetic," Madak-Erdogan said. "If they are prescribed a combination of bazedoxifene and conjugated estrogens, these symptoms often improve."
Advertisement

"We wanted to see why this drug combination is helpful, so we used a genomewide approach where we looked at the gene expression profiles in the liver," Madak-Erdogan said. "Because the liver is a major organ in metabolic control and regulates many of the chemicals in the blood, we looked at blood serum composition as well."

The scientists fed 48 eight-week-old mice a high-fat diet in which 45 percent of the calories came from fat. To mimic the low-estrogen state of menopause, 40 of the mice had their ovaries removed when they reached 10 weeks old. The mice then were randomly divided into five groups, each of which was treated for six weeks with a different combination of conjugated estrogens and bazedoxifene.

The scientists measured the mice's food intake and body weight weekly, and performed MRIs before treatment and at four weeks post-treatment to measure each animal's whole body mass and lean body mass.

After the treatment period, the scientists euthanized the mice and weighed their adipose (fat) tissue, including their white adipose tissue, which stores energy in the form of lipids; and their mesenteric and perirenal adipose tissues, two forms of abdominal fat associated with the development of type 2 diabetes, insulin resistance, inflammation and other obesity-related diseases.

Using liver samples from each treatment group, the scientists examined the expression of various genes within the mice's livers and measured the levels of nearly 150 metabolites in their blood, including cholesterol, free fatty acids and glucose.

Treatment with bazedoxifene and conjugated estrogens decreased the expression of genes along three parallel metabolic pathways that affect liver health - reducing lipid accumulation, levels of inflammation and reactive oxygen species pathways in the liver, Madak-Erdogan said.

The researchers found that eight metabolites associated with the weight and health of the liver were down-regulated by the estrogen supplements - including several metabolites known to be misregulated in people with nonalcoholic fatty liver disease.

"Treatment with conjugated estrogens and bazedoxifene also prevented the weight gain that is often associated with postmenopausal decreases in estrogen and consuming a high-fat diet," Madak-Erdogan said. "Animals in the treatment group had less fat mass and lower body weights than their peers in the control group. And their uteruses and mesenteric white adipose tissue weighed significantly less than those of their peers."

Recent studies suggesting that hormone replacement therapy increases women's risks of reproductive cancers have prompted physicians to exercise caution in prescribing hormones - despite evidence that HRT may improve women's metabolic functioning, lessen weight gain and lower their risks of serious health conditions such as cardiovascular disease and diabetes, Madak-Erdogan said.

"Although hormone therapy could reduce postmenopausal weight gain and many serious metabolic problems, physicians tend to avoid prescribing it because of concerns about elevating women's risks of reproductive cancers," Madak-Erdogan said. "Our study suggests that the combination of conjugated estrogens and bazedoxifene could improve metabolism without posing increased risk to the reproductive tissues."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
Spirituality and Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Reiki and Pranic Healing Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Estrogens Associated With Changes in Heart Physiology
Estrogens are powerful hormones important for the formation and function of the nervous, ......
Estrogen Discovery Can Treat Fertility Problems
Estrogen produced in the brain can now treat people with infertility much better. The discovery of ....
Higher Estrogen Levels Raises Alcohol Sensitivity in Brain's Reward Center
Women with elevated levels of estrogen are more vulnerable to the effects of alcohol as it ......
Role of Estrogen Receptor Activation in Brain Region at Puberty
Testosterone is involved in the formation and organization of "male" neural pathways, on which it .....
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use