About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Combination Insulin Helps Diabetics to Maintain Sugar Goals

by Ramya Rachamanti on June 10, 2019 at 6:28 PM
Font : A-A+

Combination Insulin Helps Diabetics to Maintain Sugar Goals

Diabetic patients who received insulin degludec plus liraglutide combination (IDegLira) achieved better blood glucose levels and remained in those levels longer compared to those assigned to receive insulin glargine (IGlar), according to the results of multicenter clinical trial sponsored by Novo Nordisk which are presented at the American Diabetes Association's Scientific Sessions and published simultaneously in The Lancet Diabetes & Endocrinology.

For patients with diabetes, bringing down and maintaining lower blood glucose levels is important to minimize the risk of long-term complications such as nerve damage, kidney damage, an increased risk of heart disease, eye problems, and more.

Advertisement


"We believe this reflects a more durable effect of IDegLira compared to IGlar, possibly related to the complementary roles and physiologic effects in the combination formulation," said corresponding author and global signatory investigator Vanita R. Aroda, MD, a specialist in the Division of Endocrinology, Diabetes and Hypertension at Brigham and Women's Hospital.

The study, known as DUAL VIII (Durability of insulin degludec plus liraglutide versus insulin glargine U100 as initial injectable therapy in type 2 diabetes) was a 104-week international, multicenter, open-label, phase 3b trial. It enrolled 1,012 patients who were insulin-naïve, aged 18 and older, and had HbA1c 7-11% and a BMI of 20 kg/mē or higher on stable doses of oral antidiabetic drugs.
Advertisement

Patients were randomly assigned to take insulin glargine 100 units/mL (IGlar U100) or IDegLira, which contains a GLP-1 receptor analogue -- a molecule that is similar to a naturally occurring compound that reduces blood glucose levels. Both IDegLira and IGlar were administered as once-daily injections. The primary endpoint was time to need for treatment intensification.

Patients in the IDegLira group had significantly longer time until need for intensification of treatment than those in the IGlar group. Investigators reported more effective glucose lowering, less weight gain and less risk of hypoglycemia, or low blood sugar, over the 104 weeks with the combination approach (IDegLira) compared to basal insulin alone (IGlar). No new safety or tolerability issues were reported in the trial.

In their paper, Aroda and her colleagues describe the clinical inertia that surrounds the treatment of diabetes. Concerns about weight gain, low blood sugar and fear of injectables may prevent patients from achieving better glycemic control. Although both IDegLira and IGlar were given as daily injections, IDegLira showed improved outcomes without the need for a separate, additional injection.

"IDegLira showed greater durability than IGlar U100 in reaching and maintaining patients at glycemic goals for longer, thereby minimizing the need for additional therapy, while also reducing the side effects often associated with insulin-only therapy," the authors write. "Taken together, the data from DUAL VIII illustrate the potential benefit of a combined insulin plus GLP-1RA approach, such as IDegLira, as a first injectable therapy."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Prevent Hacking of Medical Devices: FDA Sounds Alarm
Black Water: Benefits and Uses
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Diabetes and Exercise Gestational diabetes Glycemic Index Type 2 Diabetes Diabetes - Foot Care Diabesity Sugar: Time to Look beyond Its Sweetness Diabetes in Pets 

Most Popular on Medindia

Diaphragmatic Hernia Turmeric Powder - Health Benefits, Uses & Side Effects Indian Medical Journals Drug Side Effects Calculator Vent Forte (Theophylline) A-Z Drug Brands in India Nutam (400mg) (Piracetam) Iron Intake Calculator Loram (2 mg) (Lorazepam) Post-Nasal Drip

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use