Combination of a vaccine and a medicated cream was found to be a promising strategy to dramatically reduce the recurrence of genital herpes, said Yale investigators.
Their study, co-led by researchers at the University of Pennsylvania and University of Cincinnati Children's Hospital Medical Center, was published in the journal npj Vaccines.
Herpes simplex virus (HSV) type 2, which causes genital herpes, is very common, affecting more than 400 million people worldwide. There's no cure and efforts to develop a vaccine have had limited success.
The study showed that the effect of the combination therapy was far greater than either the vaccine or cream alone. "It's the first time that a study has shown that prime-and-pull strategy can block existing recurrent disease," said co-corresponding author Akiko Iwasaki, the Waldemar Von Zedtwitz Professor of Immunobiology at Yale School of Medicine.
"Development of a therapeutic HSV vaccine is a high priority. Our exciting results have encouraged us and, hopefully others, to pursue this strategy with more vaccines," said co-corresponding author David Bernstein, professor of pediatrics and former director of the Division of Infectious Diseases at Cincinnati Children's Hospital.
The study team gave three rounds of treatment to the animals, noting that the strategy worked rapidly and beginning with the first round.
Active herpes infection causes painful lesions that are physically and emotionally harmful to affected people, she noted.