The drug, which is currently being dealt on the streets of the country, is called scopolamine, but is colloquially known as 'The Devil's Breath,' and is often blown into faces of victims or added to drinks.
Within minutes, victims are like 'zombies' - coherent, but with no free will.
Some victims report being raped, forced to empty their bank accounts, and even coerced into giving up an organ.
According to the Daily Mail, Ryan Duffy of Vice - a New York City based Canadian magazine- travelled to the country to find out more about the powerful drug.
In two segments, he revealed the shocking culture of another Colombian drug world, interviewing those who deal the drug and those who have fallen victim to it.
Demencia Black, a drug dealer in the capital of Bogota, said the drug is frightening for the simplicity in which it can be administered.
He told the magazine that Scopolamine can be blown in the face of a passer-by on the street, and within minutes, that person is under the drug's effect - scopolamine is odourless and tasteless.
"You can guide them wherever you want. It's like they're a child," he explained.
Black said that one gram of Scopolamine is similar to a gram of cocaine, but later called it 'worse than anthrax.' In high doses, it is lethal.
The drug, he said, turns people into complete zombies and blocks memories from forming. So even after the drug wears off, victims have no recollection as to what happened.
One victim told Vice that a man approached her on the street asking her for directions. Since it was close by, she helped take the man to his destination, and they drank juice together.
She took the man to her house and helped him gather all of her belongings, including her boyfriend's cameras and savings.
"It is painful to have lost money," the woman said," but I was actually quite lucky."
According to the British Journal of Clinical Pharmacology, the drug - also known as hyoscine - causes the same level of memory loss as diazepam.
In ancient times, the drug was given to the mistresses of dead Colombian leaders - they were told to enter their master's grave, where they were buried alive.
In modern times, the CIA used the drug as part of Cold War interrogations, with the hope of using it like a truth serum.
However, because of the drug's chemical makeup, it also induces powerful hallucinations.
The tree from which the drug is obtained is called the 'borrachero' tree - loosely translated as the 'get-you-drunk' tree.
It is said that Colombian mothers warn their children not to fall asleep under the tree, though the leafy green canopies and large yellow and white flowers seem appealing.