The research by the Wake Forest University School of Medicine was presented at the annual Society for Neuroscience meeting in Chicago.
Lindsey Hamilton, lead researcher and a graduate student, said: "This is the first time that so many different measures of impulsivity, which is considered a risk factor for drug abuse, have been looked at in the same group of animals.
"We're looking for ways to predict which individuals are going to take drugs during their lives. It was very surprising to see that, even more than a decade after the prenatal cocaine exposure, the monkeys ended up being more impulsive and possibly more susceptible to drug use. It was particularly interesting, however, that this effect was only seen in the males. Something is either protecting the females from the effects of the cocaine exposure in the womb or making the males more susceptible to the lasting effects."
The researchers compared the impulse control of male and female adult monkeys exposed to cocaine while in the womb 15 years ago, to come up with their findings.
In one of the tests, the monkeys were given a choice between pushing a lever that let out a single banana pellet instantly or a lever that gave them several banana pellets, but for which they had had to wait for nearly five minutes.
Speaking of the experiment Hamilton said: "That's where we saw very large differences between the groups...The males who were exposed to cocaine in-utero had no patience or impulse control whatsoever."
Hamilton added: "A lot of the differences we saw were subtle.... We've done several different kinds of impulsivity tests and, on their own, each task resulted in only slight differences. But together, they paint a really clear picture of the effects of this early cocaine exposure. The more challenging the test, the more obvious the difference between the groups was.
"The fact that we are seeing differences at all is particularly striking because this is 15 years after the monkeys were exposed in the womb to cocaine... Fifteen years is the equivalent of middle age for monkeys. The fact that fairly large differences are still turning up is fascinating.
"Our studies indicate that males may be more vulnerable to the long-lasting behavioral and neurobiological consequences of cocaine exposure during gestation than females, suggesting male children who were exposed to cocaine during their mothers' pregnancies may be predisposed to abuse drugs in adulthood."