Cocaine Dependence Could Be Treated By Anti-epileptic Drug: Study

Topiramate, a drug approved by the US Food and Drug Administration (FDA) to treat epilepsy and migraine headaches, could also be the first reliable medication to help treat cocaine dependence.

The study, led by Bankole A. Johnson, DSc. MD., MB.ChB., MPhil., chairman of the Department of Psychiatry at the University of Maryland School of Medicine and head of the School's new Brain Science Research Consortium Unit, with support from the National Institutes of Health and Agency for Healthcare Research and Quality, is one of the first to establish a pharmacological treatment for cocaine addiction, for which there are currently no FDA-approved medications.

Medications to Prevent Relapse to Cocaine Use
Treatment of cocaine addiction has always been hampered by high rates of relapse, even after prolonged drug abstinence. Research teams from the Drug

Addiction affects 13.2 to 19.7 million cocaine users worldwide. Cocaine is responsible for more US emergency room visits than any other illegal drug. Cocaine harms the brain, heart, blood vessels, and lungs-and can even cause sudden death.

Professor Johnson, one of the nation's leading neuroscientists and psychopharmacologists, had previously found that topiramate was a safe and effective treatment for alcohol dependence compared with placebo.

In releasing the new study, Professor Johnson, who conducted the research when he was with Department of Psychiatry and Neurobehavioral Sciences at the University of Virginia, provided full disclosures.

Lethal Heart Condition linked To Cocaine Use
Cocaine can cause a lethal rupture in the heart’s main artery, a condition that should be suspected in people treated for chest pain. The condition

The study enrolled 142 participants, aged 18 years or older, seeking treatment for cocaine dependence.

Following enrollment, participants were randomly assigned into a topiramate group or placebo group.

Cocaine Exposure Before Birth may Impact Brain Development
Prenatal cocaine exposure may have a bunch of negative impacts on the baby's brain development and behavior

Neither the participants nor the healthcare professionals administering the treatment knew who was in which group (double-blinded study).

Using an intent-to-treat analysis, the researchers found that topiramate was more efficacious than placebo at increasing the participants' weekly proportion of cocaine nonuse days and in increasing the likelihood that participants would have cocaine-free weeks.

Brain of Cocaine Addicts Smaller In Size
In a new study, advanced imaging techniques reveals unexpected structural differences in the brains of cocaine addicts. For the study researchers

Furthermore, compared with placebo, topiramate also was significantly associated with a decrease in craving for cocaine and an improvement in participants' global functioning.

The study investigators also observed few side effects due to drug treatment.

In general, participants in the topiramate group experienced mild side-effects, including abnormal tingling skin sensations, taste distortions, anorexia, and difficulty concentrating.

The research is published in JAMA Psychiatry.

Source-ANI