About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Clinical Trial of Brain Cancer Vaccine Underway at NYU

by Medindia Content Team on October 21, 2007 at 12:50 PM
Font : A-A+

Clinical Trial of Brain Cancer Vaccine Underway at NYU

A clinical trial aimed at assessing a brain cancer vaccine in patients with newly diagnosed brain cancer has started at NYU Medical Center.

The study will examine the addition of the vaccine following standard therapy with surgery and chemotherapy in patients with glioblastoma multiforme, a deadly form of brain cancer.

Advertisement

The vaccine, called DCVax-Brain, includes proteins found in patients' tumors and is designed to hit cancer cells containing these proteins.

The study underway at NYU Medical Center is an extension of an earlier phase I trial of the vaccine, made by the Northwest Biotherapeutics, Inc., based in Bothell, Washington.
Advertisement

"We are really excited about the promise of this vaccine. Everything now depends on something in addition to surgery so that these tumors do not recur. A cancer vaccine like this may make a difference in extending life and maintaining a good quality of life," said Patrick J. Kelly, M.D., the chairman of the Department of Neurosurgery and the Joseph Ransohoff Professor of Neurosurgery at NYU School of Medicine.

NYU neuro-oncologist Michael Gruber, M.D. seconded the opinion, saying, "This is a form of individualized therapy. There is a lot of promise with this approach."

A brain cancer vaccine is intended as a kind of immunotherapy, which means that it primes the patient's own immune system to kill proteins found in cancer cells.

The trial will enroll patients 18 to 65 years old with newly diagnosed glioblastoma multiforme brain cancer who will receive standard primary treatment with surgery followed by radiation with concurrent chemotherapy. Enrolled patients will be randomized to receive the standard of care, and others will receive the standard of care and the vaccine.

The vaccine will be made from the tumors and immune cells of each patient. When a patient's tumor is removed during surgery it will be shipped to a laboratory where the tumor cells will be broken up to prepare the first component of the vaccine.

Separately, patients' dendritic cells, a powerful type of immune cell, will be obtained and sent to a laboratory for purification. Dendritic cells may be able to teach the immune system to recognize and destroy cancer cells. The patients' tumor cell material is combined with the dendritic cells to form the vaccine.

Source: ANI
SRM
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Cochlear Implants may Consequently Drive Hearing Loss
E-cigarettes Use Linked to Erectile Dysfunction
Memory Loss - Can it be Recovered?
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Clinical Trials Cancer and Homeopathy Parkinsons Disease Surgical Treatment Clinical Trials - The Past and The Future Clinical Trials - Different Phases of the trial Cancer Facts Cancer Brain Brain Facts 

Recommended Reading
Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors ....
Brain Tumor Children – Poor Performance in Schools
children who have had brain tumors perform worse in school than healthy kids, grades in foreign ......
Brain Tumor Drug in Frogs – A New Report
A synthetic version of a molecule found in the egg cells of the Northern Leopard frog (Rana ......
Clinical Trials
Clinical trials are experiments that yield useful information to clinicians if a particular treatmen...
Clinical Trials - Different Phases of the trial
Clinical trials serve as a vital component for improving the treatment of medical conditions as they...
Clinical Trials - The Past and The Future
Many of the drugs that are used today have been discovered by chance or often by mere serendipity...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use