Smoking was found to decrease the number of small blood vessels that bring oxygen and nutrients to muscles in the legs, revealed research published in The Journal of Physiology.
We know that smoking limits a person's ability to exercise because it makes their muscles weaker. It was widely believed this muscle weakness is because the lungs become inflamed and eventually destroyed by habitual smoking, therefore limiting activity and exercise.
This can impact metabolism and activity levels, both of which are risk factors for many chronic diseases including chronic obstructive pulmonary disease (COPD) and diabetes. The research conducted by the University of California, San Diego in conjunction with Universidade Federal do Rio de Janeiro and Kochi University, involved exposing mice to smoke from tobacco cigarettes for 8 weeks, either by inhalation or by injecting mice with a solution bubbled with smoke.