About Careers MedBlog Contact us

Chronic Fatigue Syndrome can Now be Identified Through Blood Bio-markers

by Dr. Trupti Shirole on March 1, 2015 at 6:03 AM
Font : A-A+

 Chronic Fatigue Syndrome can Now be Identified Through Blood Bio-markers

Chronic fatigue syndrome can now be identified through bio-markers in the blood, revealed scientists at Columbia University's Mailman School of Public Health. The study offers hope that earlier diagnosis may improve treatment. This is the first robust physical evidence that the syndrome is a biological illness as opposed to a psychological disorder, and also the first evidence that the disease has distinct stages.

With no known cause or cure, chronic fatigue syndrome, known formally as encephalomyelitis (ME/CFS), can cause extreme tiredness, headaches, difficulty concentrating and muscle pain.


Lead author Mady Hornig said, "We now have evidence confirming what millions of people with this disease already know, that ME/CFS isn't psychological. Our results should accelerate the process of establishing the diagnosis after individuals first fall ill as well as discovery of new treatment strategies focusing on these early blood markers."

Researchers tested levels of 51 immune bio-markers in blood plasma samples from 298 patients and 348 healthy controls. They found higher levels of immune molecules called cytokines in patients who had the disease three years or less. These patterns were not visible in healthy controls or patients who had the syndrome for more than three years.

Hornig said, "The association was unusually strong with a cytokine called interferon gamma that has been linked to the fatigue that follows many viral infections, including Epstein-Barr virus. However, cytokine levels did not explain symptom severity, which often fluctuates. Patients may have good days and bad days. It appears that ME/CFS patients are flush with cytokines until around the three-year mark, at which point the immune system shows evidence of exhaustion and cytokine levels drop."

Senior author W. Ian Lipkin said, "This study delivers what has eluded us for so long: unequivocal evidence of immunological dysfunction in ME/CFS and diagnostic bio-markers for disease. The question we are trying to address in a parallel microbiome project is what triggers this dysfunction."

The report appears in the journal Science Advances.

Source: Medindia


Recommended Reading

Latest Research News

What Are the Effects of Smoking on Quality of Life?
Tobacco smoke contains toxic chemicals which damage lungs, weaken the immune system and cause tuberculosis.
 Brain Shape Controls Our Thoughts, Feelings, and Behaviour
Identifying an unappreciated relationship between brain shape and activity overturns the century-old paradigm emphasizing the importance of complex brain connectivity.
Eight Threats to Black Adult's Longevity
Decoding the eight factors affecting Black adults' life expectancy.
Beyond the Campus: Contrasting Realities Revealed!
Sobering truth about foot travel in the United States emerges from international statistics, highlighting the prevalence of walking on the Blacksburg campus.
Astounding Link Between Darwin's Theory and Synaptic Plasticity  Discovered!
Unveiling a hidden mechanism, proteins within brain cells exhibit newfound abilities at synapses, reinforcing Darwin's theory of adaptation and diversity in the natural world.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Chronic Fatigue Syndrome can Now be Identified Through Blood Bio-markers Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests