About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Chinese Herbal Remedy Equivalent to Methotrexate for Treating Rheumatoid Arthritis?

by Kathy Jones on April 15, 2014 at 8:48 PM
Font : A-A+

 Chinese Herbal Remedy Equivalent to Methotrexate for Treating Rheumatoid Arthritis?

Research published online in the Annals of the Rheumatic Diseases reveals that a traditional Chinese herbal remedy used to relieve joint pain and inflammation works as well as methotrexate. The latter is a standard drug treatment that is frequently prescribed to control the symptoms of active rheumatoid arthritis.

Furthermore, combining the herbal remedy with methotrexate—the disease modifying drug (DMARD) most commonly used to treat rheumatoid arthritis—was more effective than treatment with methotrexate alone, the findings showed. Triptergium wilfordii Hook F, or TwHF for short, is used in traditional Chinese medicine to treat joint pain, swelling, and inflammation, and is already approved for the treatment of rheumatoid arthritis in China.

Advertisement

The research team randomly assigned 207 patients with active rheumatoid arthritis to one of three treatment groups: methotrexate 12.5 mg once a week; or TwHF 20 mg three times a day; or a combination of the two over a period of 24 weeks. The researchers wanted to find out which of these approaches would sufficiently alleviate symptoms to reach an ACR 50 response. This indicates a 50% improvement in the number of tender or swollen joints and other criteria including pain, disability, and the doctor's assessment of disease severity. It's a measure defined by the American College of Rheumatology. Most (174; 84%) of the participants completed the full 24 weeks of the trial. The proportion of patients achieving ACR 50 was almost 46.5% in those treated with methotrexate alone; 55% in those treated with TwHF alone; and just under 77% in those treated with both. Similar clinically significant patterns of improvement in disease activity and remission rates also occurred among the three treatment groups. There was little difference between the frequency or type of side effects experienced in the different treatment groups, although the number of women who developed irregular periods was slightly higher in those treated with TwHF. More than 300 compounds have been identified in TwHF, including diterpenoids, which experimental research suggests can suppress genes controlling inflammation and dampen down the immune response, the authors point out.

And an extract of the root has recently been investigated for its potential to treat automimmune diseases and some cancers, say the researchers. They caution that 24 weeks is too short a time to evaluate disease progression, and that the dose of methotrexate used in the trial is lower than that typically given to patients in the West. But they suggest that TwHF could be a promising approach to the treatment of active rheumatoid arthritis, particularly as not all patients respond to DMARDs, and because these drugs are expensive.
Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Rheumatoid Arthritis Saint Johns Wort High Blood Pressure and Herbs Polyarteritis Nodosa Acai Berry - Does It Really Work? Home Grown Herbs for Holistic Nutrition 

Recommended Reading
Rheumatoid Arthritis
Rheumatoid arthritis is a chronic inflammatory disease that causes pain, swelling, stiffness and ......
Hip replacement
Are you experiencing pain due to damaged hips? Travel abroad to get replacement surgery at ......
Oligoarthritis
Most parents when told that their child has arthritis find it hard to believe it, as arthritis is .....
Reiters Syndrome
Reiters syndrome, Reactive arthritis or Reiters disease is an autoimmune condition that has .....
Acai Berry - Does It Really Work?
Although acai berry is a nutritious food, it is the hype that is wrongly making it a magic fruit....
High Blood Pressure and Herbs
Drug intervention need not be the only option to help lower your moderately high blood pressure. Lif...
Home Grown Herbs for Holistic Nutrition
Creating a little kitchen garden at home is an immensely fulfilling way to incorporate healing herbs...
Polyarteritis Nodosa
Polyarteritis Nodosa (PAN) is a vasculitis that typically affects medium-sized muscular arteries. Mo...
Saint Johns Wort
Saint John''s Wort is a medicinal herb. It has been used for centuries to treat depression....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use